Outcome of life-threatening malaria in African children requiring endotracheal intubation.

Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2875 (Electronic) Linking ISSN: 14752875 NLM ISO Abbreviation: Malar J Subsets: MEDLINE

Original Publication: London : BioMed Central, [2002-

Multiple Organ Failure*; Intubation, Intratracheal/*statistics & numerical data ; Malaria, Falciparum/*complications; Child ; Child, Hospitalized ; Child, Preschool ; Cohort Studies ; Coma ; Female ; Health Surveys ; Humans ; Kaplan-Meier Estimate ; Malaria, Falciparum/mortality ; Male ; Mortality ; Proportional Hazards Models ; Retrospective Studies ; Risk ; Senegal/epidemiology ; Severity of Illness Index ; Thrombocytopenia ; Treatment Outcome

Background: Little is known about children undergoing critical care for malaria. The purpose of this survey was to evaluate the outcome in African children requiring endotracheal intubation for life-threatening malaria.
Methods: All children with a primary diagnosis of severe malaria (2000 WHO definition) requiring endotracheal intubation, hospitalised over a five-year period, within a tertiary-care hospital in Dakar, Senegal, were enrolled in a retrospective cohort study.
Results: 83 consecutive patients were included (median PRISM h24 score: 14; IQR: 10-19, multiple organ dysfunctions: 91.5%). The median duration of ventilation was 36 hrs (IQR: 4-72). Indications for intubation were deep coma (Glasgow score Conclusion: In this study, the outcome of children requiring intubation for malaria depends more on clinical presentation and progression towards organ failures than on critical care complications per se. In sub-Saharan Africa, mechanical ventilation for life-threatening childhood malaria is feasible, but seems unlikely to dramatically improve the prognosis.

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Date Created: 20070502 Date Completed: 20070524 Latest Revision: 20240414

20240414

PMC1867821

10.1186/1475-2875-6-51

17470294