Item request has been placed!
×
Item request cannot be made.
×
Processing Request
HervD Atlas: a curated knowledgebase of associations between human endogenous retroviruses and diseases.
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
- المؤلفون: Li, Cuidan1 (AUTHOR); Qian, Qiheng1,2,3 (AUTHOR); Yan, Chenghao1,3 (AUTHOR); Lu, Mingming1,2 (AUTHOR); Li, Lin4 (AUTHOR); Li, Pan1,3 (AUTHOR); Fan, Zhuojing1,2 (AUTHOR); Lei, Wenyan1,3 (AUTHOR); Shang, Kang1,3 (AUTHOR); Wang, Peihan1,3 (AUTHOR); Wang, Jie1,3 (AUTHOR); Lu, Tianyi1,3 (AUTHOR); Huang, Yuting5 (AUTHOR); Yang, Hongwei5 (AUTHOR); Wei, Haobin1,3 (AUTHOR); Han, Jingwan4 (AUTHOR); Xiao, Jingfa1,2,3 (AUTHOR) ; Chen, Fei1,3,6 (AUTHOR)
- المصدر:
Nucleic Acids Research. 1/5/2024, Vol. 52 Issue D1, pD1315-D1326. 12p.
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
Human endogenous retroviruses (HERVs), as remnants of ancient exogenous retrovirus infected and integrated into germ cells, comprise ∼8% of the human genome. These HERVs have been implicated in numerous diseases, and extensive research has been conducted to uncover their specific roles. Despite these efforts, a comprehensive source of HERV-disease association still needs to be added. To address this gap, we introduce the HervD Atlas (https://ngdc.cncb.ac.cn/hervd/), an integrated knowledgebase of HERV-disease associations manually curated from all related published literature. In the current version, HervD Atlas collects 60 726 HERV-disease associations from 254 publications (out of 4692 screened literature), covering 21 790 HERVs (21 049 HERV-Terms and 741 HERV-Elements) belonging to six types, 149 diseases and 610 related/affected genes. Notably, an interactive knowledge graph that systematically integrates all the HERV-disease associations and corresponding affected genes into a comprehensive network provides a powerful tool to uncover and deduce the complex interplay between HERVs and diseases. The HervD Atlas also features a user-friendly web interface that allows efficient browsing, searching, and downloading of all association information, research metadata, and annotation information. Overall, the HervD Atlas is an essential resource for comprehensive, up-to-date knowledge on HERV-disease research, potentially facilitating the development of novel HERV-associated diagnostic and therapeutic strategies. [ABSTRACT FROM AUTHOR]
No Comments.