Inclusion of Probiotics to Triple Antibiotic Therapy Improves the Outcome of Anti-Helicobacter pylori-Induced Peptic Ulcer.

The effects of triple antibiotic therapy plus probiotics on Helicobacter pylori-induced peptic ulcers were assessed. To this end, patients diagnosed with Helicobacter pylori-induced peptic ulcers were divided into control and treatment groups. The control group received standardized triple antibiotic (rabeprazole sodium, amoxicillin, and clarithromycin) therapy, whereas the treatment group also received Compound Eosinophil-Lactobacillus tablets for 14 consecutive days. The treatment outcomes (Helicobacter pylori eradication rate, expression levels of serum procalcitonin, high-sensitivity C-reactive protein, and interleukin-8, and incidence of adverse events) were compared. The effective rate of peptic ulcer control and the eradication rate of Helicobacter pylori were significantly higher for the treatment group than those for the control group (P < 0.05). There was also a significant reduction in pro-inflammatory markers (procalcitonin, high-sensitivity C-reactive protein, and interleukin-8) in the treatment group compared to those in the control group (P < 0.05). Also, the incidence rate of adverse events in the treatment group was lower than that of the control group, but the difference was not statistically significant (P > 0.05). In conclusion, standardized triple antibiotic therapy plus probiotics can effectively improve treatment outcomes and the Helicobacter pylori eradication rate in patients with Helicobacter pylori-induced peptic ulcer. [ABSTRACT FROM AUTHOR]

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