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Bioconjugation of Vegetable Oils with UV Absorbers: New Approach in Skin Photoprotection.
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- المؤلفون: Slabu, Andrei Iulian1,2 (AUTHOR) ; Miu, Laura1,2 (AUTHOR) ; Ghibu, Emilian1,2 (AUTHOR) ; Stavarache, Cristina Elena1,3 (AUTHOR) ; Stan, Raluca2 (AUTHOR); Teodorescu, Florina1 (AUTHOR)
- المصدر:
Molecules. Nov2023, Vol. 28 Issue 22, p7550. 12p.
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
We reported the tunable synthesis of new vegetable oil–UV filter bioconjugates using sea buckthorn oil (SBO) and p-methoxycinnamic acid (p-MCA) as an alternative to the common UV filter, ethylhexyl-p-methoxycinnamate (octinoxate). The synthetic strategy is based on the sustainable ring-opening reaction of epoxidized SBO with p-MCA in heterogenous catalysis in eco-friendly solvents. The amount of UV-absorptive moieties grafted on the triglyceride backbone is controlled by different epoxidation degrees as determined by NMR spectroscopy. The performance of the new UV-absorber bioconjugates was assessed by in vitro sun protection factor (SPF) measurements after inclusion in SBO-ethylcellulose (EC) oleogels and comparison with the SPF value of the SBO-EC-octinoxate oleogel with equivalent p-MCA acid moieties (10% wt/wt). The concentration obtained for the SBO-EC oleogel formulated with the bioconjugate with the lowest degree of functionalization, namely 55%, represents 45% of the SPF determined for the SBO-EC-octinoxate oleogel, regardless of the concentration of measured solutions. The new concept of vegetable oil–UV-absorber bioconjugates has potential UV-B photoprotective properties when included in oleogel formulations and deserves further investigation of their properties and stability including association with UV-A absorbers, respectively. [ABSTRACT FROM AUTHOR]
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