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The effects of high walnut and cashew nut diets on the antioxidant status of subjects with metabolic syndrome.

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  • معلومة اضافية
    • المصدر:
      Publisher: Steinkopff Country of Publication: Germany NLM ID: 100888704 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1436-6207 (Print) Linking ISSN: 14366207 NLM ISO Abbreviation: Eur J Nutr Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Darmstadt, Germany : Steinkopff, 1999-
    • الموضوع:
      Anacardium* ; Juglans*; Antioxidants/*administration & dosage ; Antioxidants/*metabolism ; Glutathione/*metabolism ; Metabolic Syndrome/*metabolism; Blood Glucose/metabolism ; Female ; Glutathione Disulfide/metabolism ; Humans ; Insulin/metabolism ; Lipid Metabolism/drug effects ; Lipid Metabolism/physiology ; Male ; Middle Aged ; Oxidation-Reduction ; Reactive Oxygen Species/metabolism
    • نبذة مختصرة :
      Background: Nut consumption is associated with a protective effect against coronary heart disease, partly due to its high antioxidant content. It is hypothesized that the inclusion of nuts in the diet will improve the antioxidant status of subjects with metabolic syndrome who may be vulnerable to impaired antioxidant status.
      Aim: The effects of high cashew nut and high walnut diets on the antioxidant status of subjects with metabolic syndrome are investigated.
      Methodology: Sixty-four volunteers (29 male and 35 female, 45 +/- 10y) with metabolic syndrome (diagnosed by using the ATP III criteria) received a prudent control diet, prepared in the metabolic kitchen of the North-West University, Potchefstroom campus (NWU-PC) for a period of 3 weeks (run-in). The participants were grouped according to gender and age and randomized into three groups, receiving either the walnut, cashew nut or the control diets for 8 weeks, while maintaining a stable body weight. Nuts provided 20% of daily energy intake. Fasting blood samples were taken after the run-in period (baseline) and at the end of the intervention period and analyzed for various antioxidant capacity markers.
      Results: The oxygen radical absorbance capacity (ORAC) of the walnut and cashew nut diets were significantly higher than the control diet. Despite this, the walnut and cashew nut diets had no significant effects on serum ORAC, reduced (GSH), oxidized (GSSG) glutathione, GSH:GSSG or diacron reactive metabolites (dRom) (total oxidant status) levels compared to the control group. However, all three groups showed significant improvements in antioxidant status from baseline to end (GSSG and dRom levels decreased; GSG:GSSG ratio and ORAC levels increased). This may be due to a general increased antioxidant intake from the prudent diet compared to the habitual diets.
      Conclusion: Although the inclusion of walnuts and cashew nuts into a prudent diet resulted in an increased antioxidant capacity (ORAC) of the nut diets, compared to the control diet, it did not improve the serum antioxidant profiles of subjects with metabolic syndrome.
    • References:
      Clin Chem. 1972 Jun;18(6):499-502. (PMID: 4337382)
      Clin Chem. 1995 Dec;41(12 Pt 1):1738-44. (PMID: 7497614)
      Diabetes. 2003 Sep;52(9):2346-52. (PMID: 12941775)
      J Nutr. 2001 Dec;131(12):3208-11. (PMID: 11739867)
      Nutr Rev. 1996 Aug;54(8):241-5. (PMID: 8961751)
      Ann Nutr Metab. 1991;35(3):117-27. (PMID: 1952811)
      Life Sci. 1999;64(21):1913-20. (PMID: 10353589)
      J Clin Endocrinol Metab. 2004 Oct;89(10):4963-71. (PMID: 15472192)
      Methods Enzymol. 1999;299:50-62. (PMID: 9916196)
      Blood Coagul Fibrinolysis. 2005 Sep;16(6):429-37. (PMID: 16093734)
      Diabetes Care. 2004 Dec;27(12):2777-83. (PMID: 15562184)
      J Nutr. 2001 Nov;131(11):2837-42. (PMID: 11694605)
      Isr Med Assoc J. 2002 Aug;4(8):590-3. (PMID: 12183861)
      Biosci Biotechnol Biochem. 1996 Dec;60(12):2066-8. (PMID: 8988640)
      Clin Chem. 2003 Jun;49(6 Pt 2):A2-182. (PMID: 12820598)
      Arthritis Res. 2002;4(6):R12. (PMID: 12453315)
      J Clin Endocrinol Metab. 2003 Nov;88(11):5422-6. (PMID: 14602783)
      Circulation. 2004 Apr 6;109 (13):1609-14. (PMID: 15037535)
      Nutr Cancer. 2001;39(1):66-71. (PMID: 11588904)
      Free Radic Biol Med. 1996;20(7):933-56. (PMID: 8743980)
      FASEB J. 2002 Jan;16(1):123-5. (PMID: 11709499)
      Indian J Exp Biol. 2004 Apr;42(4):373-7. (PMID: 15088687)
      J Clin Endocrinol Metab. 2000 Jul;85(7):2402-10. (PMID: 10902785)
      Phytochemistry. 2003 Aug;63(7):795-801. (PMID: 12877921)
      Am J Clin Nutr. 1997 Apr;65(4 Suppl):1203S-1209S. (PMID: 9094923)
      Diabetologia. 1996 Mar;39(3):357-63. (PMID: 8721784)
      Nutr Rev. 2001 Apr;59(4):103-11. (PMID: 11368503)
      Eur J Clin Nutr. 2003 Sep;57 Suppl 1:S8-11. (PMID: 12947444)
      Free Radic Res. 1998 Sep;29(3):257-69. (PMID: 9802557)
      Eur J Clin Nutr. 1999 Jul;53(7):523-8. (PMID: 10452406)
      Eur J Nutr. 2005 Oct;44(7):452-7. (PMID: 15782288)
      Public Health Nutr. 2001 Feb;4(1):53-62. (PMID: 11315681)
      J Nutr. 2005 Jun;135(6):1366-73. (PMID: 15930439)
      Crit Rev Food Sci Nutr. 2005;45(4):287-306. (PMID: 16047496)
      Diabetes Care. 1996 Mar;19(3):257-67. (PMID: 8742574)
    • الرقم المعرف:
      0 (Antioxidants)
      0 (Blood Glucose)
      0 (Insulin)
      0 (Reactive Oxygen Species)
      GAN16C9B8O (Glutathione)
      ULW86O013H (Glutathione Disulfide)
    • الموضوع:
      Date Created: 20070323 Date Completed: 20070730 Latest Revision: 20220408
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1007/s00394-007-0647-x
    • الرقم المعرف:
      17377830