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Chemical Composition, Antibacterial Properties, and Anti-Enzymatic Effects of Eucalyptus Essential Oils Sourced from Tunisia.
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- المؤلفون: Khedhri, Sana1 (AUTHOR) ; Polito, Flavio2 (AUTHOR) ; Caputo, Lucia2 (AUTHOR) ; De Feo, Vincenzo2,3 (AUTHOR) ; Khamassi, Marwa1 (AUTHOR) ; Kochti, Oumayama4 (AUTHOR) ; Hamrouni, Lamia1 (AUTHOR) ; Mabrouk, Yassine4 (AUTHOR) ; Nazzaro, Filomena3 (AUTHOR); Fratianni, Florinda3 (AUTHOR); Amri, Ismail4 (AUTHOR)
- المصدر:
Molecules. Oct2023, Vol. 28 Issue 20, p7211. 19p.
- الموضوع:
- معلومة اضافية
- الموضوع:
- نبذة مختصرة :
This study was conducted to examine the chemical composition of the essential oils (EOs) from six Tunisian Eucalyptus species and to evaluate their anti-enzymatic and antibiofilm activities. The EOs were obtained through hydro-distillation of dried leaves and subsequently analyzed using GC/MS. The main class of compounds was constituted by oxygenated monoterpenes, particularly prominent in E. brevifolia (75.7%), E. lehmannii (72.8%), and E. woollsiana (67%). Anti-enzymatic activities against cholinesterases, α-amylase, and α-glucosidase were evaluated using spectrophotometric methods. Notably, the E. brevifolia, E. extensa, E. leptophylla, E. patellaris, and E. woollsiana EOs displayed potent acetylcholinesterase (AChE) inhibition (IC50: 0.25–0.60 mg/mL), with E. lehmannii exhibiting lower activity (IC50: 1.2 mg/mL). E. leptophylla and E. brevifolia showed remarkable α-amylase inhibition (IC50: 0.88 mg/mL), while E. brevifolia and E. leptophylla significantly hindered α-glucosidase (IC50 < 30 mg/mL), distinguishing them from other EOs with limited effects. Additionally, the EOs were assessed for their anti-biofilm properties of Gram-positive (Staphylococcus aureus and Listeria monocytogenes) and Gram-negative (Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli) bacterial strains. The E. extensa EO demonstrated the main antibiofilm effect against E. coli and L. monocytogenes with an inhibition > 80% at 10 mg/mL. These findings could represent a basis for possible further use of Eucalyptus EOs in the treatment of human microbial infections and/or as a coadjutant in preventing and treating Alzheimer's disease and/or diabetes mellitus. [ABSTRACT FROM AUTHOR]
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