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Chronic Diarrhea Caused by Vasoactive Intestinal Peptide-Secreting Tumor.
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- المؤلفون: Belei, Oana; Basaca, Diana-Georgiana; Heredea, Elena Rodica; Iacob, Emil Radu; Olariu, Laura; Folescu, Roxana; Motoc, Andrei Gheorghe Marius; Nanu, Anda-Maria; Mărginean, Otilia
- المصدر:
Life (2075-1729); Oct2023, Vol. 13 Issue 10, p1974, 13p
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
VIPomas are a type of neuroendocrine tumor that independently produces vasoactive intestinal peptide (VIP). VIPomas causing watery diarrhea, hypokalemia, and achlorhydria (WDHA) syndrome are not frequently observed in adult patients without pancreatic ailments. However, in children, the occurrence of a VIPoma originating in the pancreas is exceedingly uncommon. Instead, WDHA syndrome is more commonly associated with neurogenic tumors that secrete VIP, often located in the retroperitoneum or mediastinum. Among infants, chronic diarrhea is a prevalent issue that often necessitates the attention of pediatric gastroenterologists. The underlying causes are diverse, and delays in arriving at a definitive diagnosis can give rise to complications affecting the overall well-being of the child. The authors present the case of an infant with chronic watery diarrhea, subocclusion manifestations, mild hypokalemia, and metabolic hyperchloremic acidosis secondary to a VIPoma in the retroperitoneum that was diagnosed via abdominal ultrasound and tomography. The laboratory results revealed lowered potassium levels and an excessive secretion of VIP. Following the surgical removal of the tumor, the diarrhea resolved, and both electrolyte levels and the imbalanced hormone levels returned to normal. Immunohistochemical examination confirmed the diagnosis of ganglioneuroblastoma, with N-MYC negative on molecular biology tests. We present the clinical and histo-genetic aspects of this rare clinical entity, with a literature review. [ABSTRACT FROM AUTHOR]
- نبذة مختصرة :
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