Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
HapX-mediated H2B deub1 and SreA-mediated H2A.Z deposition coordinate in fungal iron resistance.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
- المؤلفون: Sun, Kewei1 (AUTHOR); Li, Yiqing1 (AUTHOR); Gai, Yunpeng2 (AUTHOR); Wang, Jingrui1 (AUTHOR); Jian, Yunqing1 (AUTHOR); Liu, Xin3 (AUTHOR); Wu, Liang4 (AUTHOR); Shim, Won-Bo5 (AUTHOR); Lee, Yin-Won6 (AUTHOR); Ma, Zhonghua1 (AUTHOR); Haas, Hubertus7 (AUTHOR) ; Yin, Yanni1 (AUTHOR)
- المصدر:
Nucleic Acids Research. 10/27/2023, Vol. 51 Issue 19, p10238-10260. 23p.
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
Plant pathogens are challenged by host-derived iron starvation or excess during infection, but the mechanism through which pathogens counteract iron stress is unclear. Here, we found that Fusarium graminearum encounters iron excess during the colonization of wheat heads. Deletion of h eme a ctivator p rotein X (FgHapX), s ideropho re transcription factor A (FgSreA) or both attenuated virulence. Further, we found that FgHapX activates iron storage under iron excess by promoting histone H2B deubiquitination (H2B deub1) at the promoter of the responsible gene. Meanwhile, FgSreA is shown to inhibit genes mediating iron acquisition during iron excess by facilitating the deposition of histone variant H2A.Z and histone 3 lysine 27 trimethylation (H3K27 me3) at the first nucleosome after the transcription start site. In addition, the monothiol g luta r edo x in FgGrx4 is responsible for iron sensing and control of the transcriptional activity of FgHapX and FgSreA via modulation of their enrichment at target genes and recruitment of epigenetic regulators, respectively. Taken together, our findings elucidated the molecular mechanisms for adaptation to iron excess mediated by FgHapX and FgSreA during infection in F. graminearum and provide novel insights into regulation of iron homeostasis at the chromatin level in eukaryotes. [ABSTRACT FROM AUTHOR]
No Comments.