Genetic and antigenic characteristics of zoonotic influenza A viruses and development of candidate vaccine viruses for pandemic preparedness.

Caractéristiques génétiques et antigéniques des virus grippaux A zoonotiques et mise au point de virus vaccinaux candidats pour se préparer à une pandémie.

INFLUENZA vaccines; INFLUENZA A virus; VIRAL vaccines; PHYLOGENY; MICROBIAL genetics; ZOONOSES; VACCINE development; H5N1 Influenza; PANDEMIC preparedness; EMERGENCY management; EPIDEMICS; INFLUENZA A virus, H1N1 subtype; INFLUENZA A virus, H3N2 subtype

The article summarizes the genetic and antigenic characteristics of zoonotic influenza viruses and related viruses circulating in animals that are relevant to the development by the World Health Organization (WHO) of candidate vaccine viruses (CVV) for pandemic preparedness. Cited are updates on the characterization of A/goose/Guangdong/1/96-lineage Avian influenza A(H5) viruses and the status of the development of influenza A(H5) CVV and influenza activity from February 21-September 25, 2023.