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Impact of Induction Immunosuppressants on T Lymphocyte Subsets after Kidney Transplantation: A Prospective Observational Study with Focus on Anti-Thymocyte Globulin and Basiliximab Induction Therapies.
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- المؤلفون: Kim, Hyung Duk1 (AUTHOR) ; Bae, Hyunjoo2 (AUTHOR) ; Yun, Sojeong2 (AUTHOR) ; Lee, Hanbi3 (AUTHOR) ; Eum, Sang Hun4 (AUTHOR) ; Yang, Chul Woo3 (AUTHOR) ; Oh, Eun-Jee5,6 (AUTHOR) ; Chung, Byung Ha3 (AUTHOR)
- المصدر:
International Journal of Molecular Sciences. Sep2023, Vol. 24 Issue 18, p14288. 14p.
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
Induction immunosuppressive therapy for kidney transplant recipients (KTRs) primarily includes interleukin-2 receptor antagonists, such as basiliximab (BXM) or lymphocyte-depleting agents, and anti-thymocyte globulin (ATG). This study aimed to investigate their effects on T cell dynamics during the early post-transplantation period. This prospective observational study included 157 KTRs. Peripheral blood samples were collected from each patient within 5 days before and 4 and 12 weeks after transplantation. Flow cytometric analysis was performed to assess various T cell subsets whose changes were then analyzed. In the ATG group, CD4+ T cell expression decreased significantly compared with that in the BXM group. However, CD4+CD161+ and CD4+CD25+CD127low T cell expression levels increased significantly. In the CD8+ T cell subset, a decrease in CD8+CD28nullCD57+ and CD8+CCR7+ T cell expression was observed in the ATG group. However, among patients diagnosed with biopsy-proven acute rejection, T cell subset expression did not significantly differ relative to non-rejection cases. In conclusion, ATG induction therapy resulted in more pronounced changes in T lymphocyte subsets than BXM induction, with increased CD4+CD161+ and CD4+CD25+CD127low T cells and an early decrease in CD8+CD28nullCD57+ and CD8+CCR7+ T cells, some of which are associated with acute rejection. [ABSTRACT FROM AUTHOR]
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