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2,3,7,8-Tetrachlorodibenzo-p-dioxin affects fluctuating asymmetry of molar shape in mice, and an epistatic interaction of two genes for molar size.

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  • المؤلفون: Keller JM;Keller JM; Allen DE; Davis CR; Leamy LJ
  • المصدر:
    Heredity [Heredity (Edinb)] 2007 May; Vol. 98 (5), pp. 259-67. Date of Electronic Publication: 2007 Jan 10.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0373007 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0018-067X (Print) Linking ISSN: 0018067X NLM ISO Abbreviation: Heredity (Edinb) Subsets: MEDLINE
    • بيانات النشر:
      Publication: <2003->: London : Nature Publishing Group
      Original Publication: London, Oliver and Boyd.
    • الموضوع:
      Epistasis, Genetic* ; Quantitative Trait Loci*; Genes/*physiology ; Mandible/*abnormalities ; Molar/*anatomy & histology ; Polychlorinated Dibenzodioxins/*toxicity ; Teratogens/*toxicity; Animals ; Genetic Markers ; Mice ; Mice, Inbred AKR ; Mice, Inbred C57BL
    • نبذة مختصرة :
      Fluctuating asymmetry (FA), random variation between left and right sides in a bilaterally symmetrical character, is a commonly used measure of developmental instability that is expected to increase with increasing environmental stress. One potential stressor is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a powerful toxicant known to disturb tooth development. In this study, mice in the F(2) generation produced from an intercross between two inbred strains (C57BL/6J and AKR/J) were exposed in utero to TCDD. We hypothesized that TCDD would increase FA in the molars of exposed mice over that of the control mice. In addition, we hypothesized that we would discover genes for molar size, shape or asymmetry whose expression would be affected by TCDD. We detected a very small, but significant, increase in FA of molar shape (but not size) in the TCDD-exposed mice compared to the control mice, although molar size and shape did not differ between these groups. Although we did not uncover any genes that acted differently in the TCDD exposed and control groups, we did identify two genes whose dominance by additive epistatic effect on molar size was affected by TCDD. We concluded that although TCDD may be affecting the expression of some genes governing the development of molars in our population of mice, FA of molar size and shape is not a particularly sensitive indicator of this effect.
    • الرقم المعرف:
      0 (Genetic Markers)
      0 (Polychlorinated Dibenzodioxins)
      0 (Teratogens)
    • الموضوع:
      Date Created: 20070111 Date Completed: 20070531 Latest Revision: 20161124
    • الموضوع:
      20221213
    • الرقم المعرف:
      10.1038/sj.hdy.6800928
    • الرقم المعرف:
      17213866