Biosignals modulated by tumor-associated carbohydrate antigens: novel targets for cancer therapy.

Publisher: New York Academy of Sciences Country of Publication: United States NLM ID: 7506858 Publication Model: Print Cited Medium: Print ISSN: 0077-8923 (Print) Linking ISSN: 00778923 NLM ISO Abbreviation: Ann N Y Acad Sci Subsets: MEDLINE

Publication: 2006- : New York, NY : Malden, MA : New York Academy of Sciences ; Blackwell
Original Publication: New York, The Academy.

Cell Proliferation/*drug effects ; Gangliosides/*physiology ; Glycosphingolipids/*metabolism; Anoikis/drug effects ; Anoikis/physiology ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Carcinoma, Small Cell/metabolism ; Carcinoma, Small Cell/pathology ; Cell Line, Tumor ; Crk-Associated Substrate Protein/metabolism ; Focal Adhesion Protein-Tyrosine Kinases/metabolism ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Melanoma/metabolism ; Melanoma/pathology ; Neoplasm Invasiveness ; Paxillin/metabolism ; Phosphorylation ; Tyrosine/metabolism

Based on the remodeling of glycosphingolipids on the human tumor cell lines with manipulation of glycosyltransferase genes, roles of sugar moieties in tumor-associated carbohydrate antigens have been analyzed. Two main topics, that is, the roles of ganglioside GD3 in human malignant melanomas and those of GD2 in small cell lung cancer (SCLC) were reported. GD3 enhances tyrosine phosphorylation of two adaptor molecules, p130Cas and paxillin, resulting in the increased cell growth and invasion in melanoma cells. GD2 also enhances the proliferation and invasion of SCLC cells. GD2 also mediates apoptosis with anti-GD2 monoclonal antibodies (mAbs) via dephosphorylation of the focal adhesion kinase. These approaches have promoted further understanding of mechanisms by which gangliosides modulate malignant properties of human cancer, and the results obtained here propose novel targets for cancer therapy.

39

0 (Antibodies, Monoclonal)
0 (BCAR1 protein, human)
0 (Crk-Associated Substrate Protein)
0 (Gangliosides)
0 (Glycosphingolipids)
0 (Paxillin)
42HK56048U (Tyrosine)
62010-37-1 (ganglioside, GD3)
65988-71-8 (ganglioside, GD2)
EC 2.7.10.2 (Focal Adhesion Protein-Tyrosine Kinases)

Date Created: 20061223 Date Completed: 20070213 Latest Revision: 20131121

20221213

10.1196/annals.1377.017

17185516