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IgE-activated mast cells in combination with pro-inflammatory factors induce Th2-promoting dendritic cells.

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  • معلومة اضافية
    • المصدر:
      Publisher: [Oxford University Press Country of Publication: England NLM ID: 8916182 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0953-8178 (Print) Linking ISSN: 09538178 NLM ISO Abbreviation: Int Immunol Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Oxford : [Oxford University Press, 1989-
    • الموضوع:
      Dendritic Cells/*immunology ; Immunoglobulin E/*immunology ; Inflammation/*immunology ; Mast Cells/*immunology ; Th2 Cells/*immunology; Cell Differentiation ; Cells, Cultured ; Dendritic Cells/cytology ; Dermatitis, Atopic/immunology ; Female ; Fetal Blood ; Humans ; Interleukin-12/immunology ; Th2 Cells/cytology
    • نبذة مختصرة :
      Dendritic cells (DCs) and mast cells (MCs) co-localize in peripheral tissues of antigen entry, i.e. skin and mucosa. Due to the proximity of these two cell types, activation of MCs may affect DC functions. Here, we co-cultured human monocyte-derived DCs with cord blood-derived MCs activated by cross-linking of FcepsilonRI to elucidate the net effect of the whole MC products on DCs. Activated MCs induced maturation of DCs, and potently suppressed IL-12p70 production by the DCs. Whereas co-culture of DCs with activated MCs alone did not significantly influence the type of CD4(+) T cell responses induced by the DCs, DCs co-cultured with activated MCs in the presence of pro-inflammatory or T(h)1-inducing factors caused T(h)2 polarization. Although histamine was involved in the induction of DC maturation and T(h)2 polarization by activated MCs, a combinatorial effect of various MC-derived factors, including those acting in a cell contact-dependent manner, was required for the optimal induction of T(h)2-promoting DCs. Furthermore, we demonstrated that clusters of DCs are located closely with MCs in lesions of atopic dermatitis. Collectively, this study suggests that the interaction between DCs and IgE-activated MCs in a pro-inflammatory or even T(h)1-prone environment is instrumental in maintaining and augmenting T(h)2 responses in allergy, and that disruption of the DC-MC interaction may constitute an effective strategy to treat ongoing allergic diseases.
    • الرقم المعرف:
      187348-17-0 (Interleukin-12)
      37341-29-0 (Immunoglobulin E)
    • الموضوع:
      Date Created: 20061028 Date Completed: 20070122 Latest Revision: 20061127
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.1093/intimm/dxl113
    • الرقم المعرف:
      17068106