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Effect of docosahexaenoic acid intake on lipid peroxidation in diabetic rat retina under oxidative stress.

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  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 9423872 Publication Model: Print Cited Medium: Print ISSN: 1071-5762 (Print) Linking ISSN: 10292470 NLM ISO Abbreviation: Free Radic Res Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: Yverdon, Switzerland : New York, NY : Harwood Academic ; distributed by STBS Ltd., c1994-
    • الموضوع:
      Oxidative Stress*; Diabetes Mellitus, Experimental/*drug therapy ; Docosahexaenoic Acids/*pharmacokinetics ; Lipid Peroxidation/*drug effects ; Retina/*drug effects; Animals ; Antioxidants/metabolism ; Free Radicals ; Lipid Peroxides/chemistry ; Malondialdehyde/metabolism ; Rats ; Rats, Sprague-Dawley ; Vitamin E/metabolism
    • نبذة مختصرة :
      Docosahexaenoic acid (DHA) plays an important role in visual function but has a highly oxidation-prone chemical structure. Therefore, we investigated how dietary DHA affects the generation of lipid peroxides in rat retina under oxidative stress in diabetes with/without vitamin E (VE) deficiency. Streptozotocin-induced (50 mg i.p./kg B.W.) diabetic Sprague-Dawley (SD) rats were assigned to four groups: (i) control/VE(+), (ii) DHA/VE(+), (iii) control/VE( - ) and (iv) DHA/VE( - ), and raised for 28 days. We then measured lipid peroxide levels in the retina, serum and liver. With a normal intake of VE, dietary DHA increased only the retinal level of thiobarbituric acid-reactive substances (TBARS) slightly. In contrast, in rats with VE deficiency, dietary DHA increased serum and liver lipid peroxide levels but not in the retina. These results suggest that dietary DHA does not necessarily promote lipid peroxidation in the retina even under high oxidative stress.
    • الرقم المعرف:
      0 (Antioxidants)
      0 (Free Radicals)
      0 (Lipid Peroxides)
      1406-18-4 (Vitamin E)
      25167-62-8 (Docosahexaenoic Acids)
      4Y8F71G49Q (Malondialdehyde)
    • الموضوع:
      Date Created: 20061004 Date Completed: 20070111 Latest Revision: 20131121
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.1080/10715760600719557
    • الرقم المعرف:
      17015262