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The relationship between longer leukocyte telomeres and dNCR in non-cardiac surgery patients: a retrospective analysis.
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- المؤلفون: Liu, Chen1,2; Ding, Ke1,3; Abdul, Mannan1,4; Sun, Qing-Chun1,5; Zhang, Zhen-Feng1,5; Dong, Meng-Meng1,6; Han, Liu1; Dai, Ming-Sheng1; Guan, Hui-Lian1; Han, Yuan1,4; Liu, He1,7 ; Chen, Xue-Fen8 ; Cao, Jun-Li1,6
- المصدر:
BMC Anesthesiology. 8/22/2023, Vol. 23 Issue 1, p1-8. 8p.
- الموضوع:
- معلومة اضافية
- الموضوع:
- نبذة مختصرة :
Background: Cognitive decline following surgery is a common concern among elderly individuals. Leukocyte telomere length (LTL) can be assessed as a biological clock connected to an individual lifespan. However, the mechanisms causing this inference are still not fully understood. As a result of this, LTL has the potential to be useful as an aging-related biomarker for assessing delayed neurocognitive recovery (dNCR) and related diseases. Methods: For this study, 196 individuals over 60 who were scheduled due to major non-cardiac surgical operations attended neuropsychological testing before surgery, followed by additional testing one week later. The finding of dNCR was based on a measured Z-score ≤ -1.96 on two or more separate tests. The frequency of dNCR was presented as the primary outcome of the study. Secondly, we evaluated the association between dNCR and preoperative LTL. Results: Overall, 20.4% [40/196; 95% confidence interval (CI), 14.7–26.1%] of patients exhibited dNCR 1-week post-surgery. Longer LTL was identified as a predictor for the onset of early cognitive impairment resulting in postoperative cognitive decline [odds ratio (OR), 14.82; 95% CI, 4.01–54.84; P < 0.001], following adjustment of age (OR, 12.33; 95% CI, 3.29–46.24; P < 0.001). The dNCR incidence based on LTL values of these patients, the area under the receiver operating characteristic (ROC) curve was 0.79 (95% CI, 0.722–0.859; P < 0.001). At an optimal cut-off value of 0.959, LTL values offered respective specificity and sensitivity values of 64.7% and 87.5%. Conclusions: In summary, the current study revealed that the incidence of dNCR was strongly associated with prolonged LTL. Furthermore, this biomarker could help identify high-risk patients and offer insight into the pathophysiology of dNCR. [ABSTRACT FROM AUTHOR]
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