Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

RNA-protein interactions at the initial and terminal stages of protein biosynthesis as investigated by Lev Kisselev (on the occasion of his 70th anniversary).

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Bogdanov AA;Bogdanov AA; Karpov VL
  • المصدر:
    Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2006 Aug; Vol. 71 (8), pp. 915-24.
  • نوع النشر :
    Biography; Historical Article; Journal Article; Review
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: MAIK Nauka/Interperiodica Country of Publication: United States NLM ID: 0376536 Publication Model: Print Cited Medium: Print ISSN: 0006-2979 (Print) Linking ISSN: 00062979 NLM ISO Abbreviation: Biochemistry (Mosc) Subsets: MEDLINE
    • بيانات النشر:
      Publication: <2007->: Moscow : MAIK Nauka/Interperiodica
      Original Publication: New York, Consultants Bureau [etc.]
    • الموضوع:
      Protein Biosynthesis*; Amino Acyl-tRNA Synthetases/history ; Amino Acyl-tRNA Synthetases/metabolism ; History, 20th Century ; History, 21st Century ; Peptide Chain Initiation, Translational ; Peptide Chain Termination, Translational ; Peptide Termination Factors/history ; Peptide Termination Factors/metabolism ; RNA, Transfer/genetics ; RNA, Transfer/history ; RNA, Transfer/metabolism
    • الموضوع:
      Kisselev LL
    • نبذة مختصرة :
      This review highlights studies by Lev L. Kisselev and his colleagues on the initial and terminal stages of protein biosynthesis, which cover the period of the last 45 years (1961-2006). They investigated spatial structure of tRNAs, structure and functions of aminoacyl-tRNA-synthetases of higher organisms, and the final step of protein synthesis, termination of translation. L. Kisselev and his team have made three major contributions to these fields of molecular biology; (i) they proposed the hypothesis on the role of anticodon triplet of tRNA in recognition by cognate aminoacyl-tRNA synthetase, which has been experimentally confirmed and is now included in textbooks; (ii) identified primary structures and functions of two eukaryotic protein factors (eRF1 and eRF3) playing a pivotal role in translation termination; (iii) characterized a structural basis for stop codon recognition by eRF1 within the ribosome and discovered the negative structural elements of eRF1, limiting its recognition of one or two stop-codons.
    • Number of References:
      146
    • الرقم المعرف:
      0 (Peptide Termination Factors)
      9014-25-9 (RNA, Transfer)
      EC 6.1.1.- (Amino Acyl-tRNA Synthetases)
    • الموضوع:
      Date Created: 20060919 Date Completed: 20070112 Latest Revision: 20190917
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1134/s0006297906080141
    • الرقم المعرف:
      16978156