Olopatadine suppresses the migration of THP-1 monocytes induced by S100A12 protein.

Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 9209001 Publication Model: Print Cited Medium: Print ISSN: 0962-9351 (Print) Linking ISSN: 09629351 NLM ISO Abbreviation: Mediators Inflamm Subsets: MEDLINE

Publication: 2005- : Sylvania, OH : Hindawi Pub. Corp.
Original Publication: Oxford, UK : Rapid Communications of Oxford Ltd., c1992-

Gene Expression Regulation*; Dibenzoxepins/*pharmacology ; Histamine H1 Antagonists, Non-Sedating/*pharmacology ; Monocytes/*cytology ; S100 Proteins/*physiology; Aminopyridines/pharmacology ; Cell Culture Techniques/methods ; Cell Movement ; Histamine H1 Antagonists/pharmacology ; Humans ; Inflammation ; Ketotifen/pharmacology ; Olopatadine Hydrochloride ; Receptors, Histamine H1/metabolism ; S100 Proteins/metabolism ; S100A12 Protein

Olopatadine hydrochloride (olopatadine) is an antiallergic drug with histamine H(1) receptor antagonistic activity. Recently, olopatadine has been shown to bind to S100A12 which is a member of the S100 family of calcium-binding proteins, and exerts multiple proinflammatory activities including chemotaxis for monocytes and neutrophils. In this study, we examined the possibility that the interaction of olopatadine with S100A12 inhibits the proinflammatory effects of S100A12. Pretreatment of olopatadine with S100A12 reduced migration of THP-1, a monocyte cell line, induced by S100A12 alone, but did not affect recombinant human regulated upon activation, normal T cell expressed and secreted (RANTES)-induced migration. Amlexanox, which also binds to S100A12, inhibited the THP-1 migration induced by S100A12. However, ketotifen, another histamine H(1) receptor antagonist, had little effect on the activity of S100A12. These results suggest that olopatadine has a new mechanism of action, that is, suppression of the function of S100A12, in addition to histamine H(1) receptor antagonistic activity.

Eur J Biochem. 2001 Jan;268(2):353-63. (PMID: 11168370)
Br J Dermatol. 2004 Dec;151(6):1133-42. (PMID: 15606507)
J Leukoc Biol. 2001 Jun;69(6):986-94. (PMID: 11404386)
Jpn J Pharmacol. 2001 Oct;87(2):167-70. (PMID: 11700017)
Biochem Biophys Res Commun. 2002 Apr 12;292(4):1023-30. (PMID: 11944917)
Jpn J Pharmacol. 2002 Apr;88(4):379-97. (PMID: 12046981)
Jpn J Pharmacol. 2002 Apr;88(4):463-6. (PMID: 12046991)
J Cell Biol. 2002 Jul 22;158(2):201-8. (PMID: 12135982)
Microsc Res Tech. 2003 Apr 15;60(6):581-92. (PMID: 12645006)
Clin Immunol. 2003 Apr;107(1):46-54. (PMID: 12738249)
Eur J Biochem. 2004 Sep;271(18):3765-75. (PMID: 15355353)
Lancet. 1990 Sep 29;336(8718):763-5. (PMID: 1976144)
J Infect Dis. 1991 Jan;163(1):187-92. (PMID: 1984467)
J Immunol. 1994 Feb 15;152(4):1888-97. (PMID: 8120396)
Adv Exp Med Biol. 1995;371A:201-6. (PMID: 8525906)
Trends Biochem Sci. 1996 Apr;21(4):134-40. (PMID: 8701470)
J Biol Chem. 1998 Aug 28;273(35):22224-31. (PMID: 9712836)
Biochem J. 1999 Mar 15;338 ( Pt 3):583-9. (PMID: 10051426)
Protein Expr Purif. 1999 Jun;16(1):47-52. (PMID: 10336859)
Cell. 1999 Jun 25;97(7):889-901. (PMID: 10399917)
FEBS Lett. 2001 Jan 12,;488(1-2):85-90. (PMID: 11163801)

0 (Aminopyridines)
0 (Dibenzoxepins)
0 (Histamine H1 Antagonists)
0 (Histamine H1 Antagonists, Non-Sedating)
0 (Receptors, Histamine H1)
0 (S100 Proteins)
0 (S100A12 Protein)
0 (S100A12 protein, human)
2XG66W44KF (Olopatadine Hydrochloride)
BRL1C2459K (amlexanox)
X49220T18G (Ketotifen)

Date Created: 20060726 Date Completed: 20070111 Latest Revision: 20181113

20221213

PMC1570388

10.1155/MI/2006/42726

16864903