Expressed MHC class II genes in sea otters (Enhydra lutris) from geographically disparate populations.

Publisher: Wiley Blackwell Country of Publication: England NLM ID: 0331072 Publication Model: Print Cited Medium: Print ISSN: 0001-2815 (Print) Linking ISSN: 00012815 NLM ISO Abbreviation: Tissue Antigens Subsets: MEDLINE

Publication: <2015>: [Oxford] : Wiley Blackwell
Original Publication: 1971- : Copenhagen, Munksgaard.

Gene Expression*; Genes, MHC Class II/*genetics ; Histocompatibility Antigens Class II/*classification ; Histocompatibility Antigens Class II/*genetics ; Otters/*genetics; Alaska ; Amino Acid Sequence ; Animals ; Base Sequence ; California ; Leukocytes/chemistry ; Leukocytes/immunology ; Molecular Sequence Data ; Otters/metabolism ; Phylogeny ; RNA, Messenger/analysis ; RNA, Messenger/metabolism ; Washington

The major histocompatibility complex (MHC) is central to maintaining the immunologic vigor of individuals and populations. Classical MHC class II genes were targeted for partial sequencing in sea otters (Enhydra lutris) from populations in California, Washington, and Alaska. Sequences derived from sea otter peripheral blood leukocyte mRNAs were similar to those classified as DQA, DQB, DRA, and DRB in other species. Comparisons of the derived amino acid compositions supported the classification of these as functional molecules from at least one DQA, DQB, and DRA locus and at least two DRB loci. While limited in scope, phylogenetic analysis of the DRB peptide-binding region suggested the possible existence of distinct clades demarcated by geographic region. These preliminary findings support the need for additional MHC gene sequencing and expansion to a comprehensive study targeting additional otters.

0 (Histocompatibility Antigens Class II)
0 (RNA, Messenger)

Date Created: 20060505 Date Completed: 20060728 Latest Revision: 20060504

20240829

10.1111/j.1399-0039.2006.00559.x

16671948