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Prevalence of atherosclerosis in relation to atomic bomb radiation exposure: an RERF Adult Health Study.

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  • المؤلفون: Yamada M;Yamada M; Naito K; Kasagi F; Masunari N; Suzuki G
  • المصدر:
    International journal of radiation biology [Int J Radiat Biol] 2005 Nov; Vol. 81 (11), pp. 821-6.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 8809243 Publication Model: Print Cited Medium: Print ISSN: 0955-3002 (Print) Linking ISSN: 09553002 NLM ISO Abbreviation: Int J Radiat Biol Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London ; New York : Taylor & Francis, [c1988-
    • الموضوع:
      Nuclear Warfare*; Atherosclerosis/*epidemiology ; Environmental Exposure/*analysis ; Radioactive Fallout/*analysis ; Risk Assessment/*methods ; Survivors/*statistics & numerical data; Aged ; Aged, 80 and over ; Body Burden ; Comorbidity ; Cross-Sectional Studies ; Female ; Humans ; Japan/epidemiology ; Male ; Middle Aged ; Prevalence ; Relative Biological Effectiveness ; Risk Factors ; Statistics as Topic
    • نبذة مختصرة :
      Purpose: To determine whether exposure to atomic bomb radiation altered the prevalence of asymptomatic atherosclerosis.
      Material and Methods: In a cross-sectional analysis, we examined aortic arch calcification by plain chest radiography and common carotid artery intima-media thickness (IMT) by ultrasonography among 1804 survivors of the atomic bombing in Hiroshima. We evaluated the association between atherosclerotic changes and radiation exposure, while adjusting for potentially confounding factors.
      Results: Multivariate logistic regression analysis showed that aortic arch calcification was significantly associated with radiation exposure (p < 0.05). The odds ratio at 1 Gy was 1.30 (95% confidence interval [CI]: 1.05 - 1.53) for men and 1.31 (95% CI: 1.13 - 1.51) for women. Carotid artery IMT did not vary significantly with radiation dose (p = 0.18).
      Conclusion: Radiation dose contributed to the prevalence of aortic atherosclerosis but not carotid artery atherosclerosis in atomic bomb survivors.
    • الرقم المعرف:
      0 (Radioactive Fallout)
    • الموضوع:
      Date Created: 20060218 Date Completed: 20060426 Latest Revision: 20071115
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1080/09553000600555504
    • الرقم المعرف:
      16484151