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Eating your mitochondria—when too much of a good thing turns bad.

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  • معلومة اضافية
    • نبذة مختصرة :
      How mitophagy is turned on to remove damaged or excess mitochondria from cells has been well‐studied, but less is known about how the pathway is turned off to avoid "over‐eating" of mitochondria under basal conditions. Three new studies now reveal the disease‐associated FBXL4 protein as an important negative regulator of constitutive mitophagy, controlling the stability of mitophagy receptors BNIP3 and NIX. [ABSTRACT FROM AUTHOR]