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A novel nano material for anti-cerebral ischaemia: preparation and application of borneol angelica polysaccharide liposomes.
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- المؤلفون: Ding, Huang; Wang, Ke; He, Lin-Qin; Yang, Xiao-Yu; Huang, Hai-Hong; Liu, Wen-Long; Xiao, Chen; Du, Ze- Xuan; Yu, Lian-; Zhang, Wei
- المصدر:
Journal of Liposome Research; Jun2023, Vol. 33 Issue 2, p144-153, 10p
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
Objective: To investigate the preparation of novel nanoliposomes (Borneol Angelica Polysaccharide Liposomes, BAPL) for anti-cerebral ischaemia and verify its curative effects and mechanism. Methods: By applying a uniform experiment design to investigate the fitting combination of BAPL. Encapsulation Efficiency Evaluation of BAPL Preparation; Particle Size and Surface Potential Evaluation of BAPL Biological activity; Cerebral ischaemia models of rats Evaluation of BAPL curative effects and mechanism. Results: (1) The fitting combination of lecithin, Cholesterol, AP mass and the borneol mass was 60 mg, 60 mg, 45 mg and 5 mg. the highest encapsulation efficiency was 80.4%, the particle size was 179.1 nm, and the surface zeta potential was −17.2 mV. It conforms to the nano-material standards. (2) The results of animal experiments show that: In the BAPL group, the infarct volume of TTC staining was significantly decreased, and the expression levels of NF-κBp65, TLR-4, IL-8, IL-6, IL-1β in brain tissue were significantly decreased, while the expression levels of ZO-1, ZO-2, IL-10 were significantly increased after cerebral ischaemia-reperfusion. Conclusion: BAPL is a novel nano and effective material for anti-cerebral ischaemia. [ABSTRACT FROM AUTHOR]
- نبذة مختصرة :
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