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Misdiagnosis of Clostridioides difficile Infections by Standardof- Care Specimen Collection and Testing among Hospitalized Adults, Louisville, Kentucky, USA, 2019–20201.
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- المؤلفون: Ramirez, Julio A.1; Angulo, Frederick J.2 ; Carrico, Ruth M.1,3; Furmanek, Stephen1,3; Oliva, Senén Peña1; Zamparo, Joann M.2; Gonzalez, Elisa2; Zhang, Pingping2; Wolf Parrish, Leslie A.1; Marimuthu, Subathra1; Pride, Michael W.4; Gray, Sharon2; Matos Ferreira, Cátia S.2,5; Arnold, Forest W.1; Istúriz, Raul E.2; Minarovic, Nadia2; Moïsi, Jennifer C.2; Jodar, Luis2
- المصدر:
Emerging Infectious Diseases. May2023, Vol. 29 Issue 5, p919-928. 10p. 2 Diagrams, 5 Charts.
- الموضوع:
- معلومة اضافية
- الموضوع:
- نبذة مختصرة :
Although Clostridioides difficile infection (CDI) incidence is high in the United States, standard-of-care (SOC) stool collection and testing practices might result in incidence overestimation or underestimation. We conducted diarrhea surveillance among inpatients >50 years of age in Louisville, Kentucky, USA, during October 14, 2019–October 13, 2020; concurrent SOC stool collection and CDI testing occurred independently. A study CDI case was nucleic acid amplification test‒/cytotoxicity neutralization assay‒positive or nucleic acid amplification test‒positive stool in a patient with pseudomembranous colitis. Study incidence was adjusted for hospitalization share and specimen collection rate and, in a sensitivity analysis, for diarrhea cases without study testing. SOC hospitalized CDI incidence was 121/100,000 population/year; study incidence was 154/100,000 population/ year and, in sensitivity analysis, 202/100,000 population/ year. Of 75 SOC CDI cases, 12 (16.0%) were not study diagnosed; of 109 study CDI cases, 44 (40.4%) were not SOC diagnosed. CDI incidence estimates based on SOC CDI testing are probably underestimated. [ABSTRACT FROM AUTHOR]
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