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Causes and characteristics of unexpected sudden cardiac death in octogenarians/nonagenarians.
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- المؤلفون: Puolitaival, Elisa1 (AUTHOR); Vähätalo, Juha1 (AUTHOR); Holmström, Lauri1 (AUTHOR); Haukilahti, M. Anette E.1 (AUTHOR); Pakanen, Lasse2,3 (AUTHOR); Ukkola, Olavi H.1 (AUTHOR); Junttila, M. Juhani1 (AUTHOR); Huikuri, Heikki V.1 (AUTHOR); Perkiömäki, Juha S.1 (AUTHOR)
- المصدر:
PLoS ONE. 4/20/2023, Vol. 17 Issue 4, p1-13. 13p.
- الموضوع:
- معلومة اضافية
- الموضوع:
- نبذة مختصرة :
Introduction: The risk for sudden cardiac death (SCD) increases with ageing. Methods: We evaluated causes and characteristics of unexpected SCD in SCD victims aged ≥ 80 years in a consecutive series of 5,869 SCD victims in Northern Finland. All the victims underwent medico-legal autopsy as medico-legal autopsy is mandatory in cases of unexpected sudden death in Finland. All the non-cardiac deaths such as pulmonary embolism and cerebral hemorrhage were excluded from the study, as were unnatural deaths such as intoxications. Results: Among SCD victims ≥ 80 years, 91.0% of SCDs were due to ischemic heart disease (IHD) determined in autopsy and 9.0% due to non-ischemic heart disease (NIHD), whereas among those < 80 years, only 72.6% of SCDs were due to IHD and 27.4% due to NIHD (P <.001). Severe fibrosis in myocardium was more common whereas heart weight and liver weight, body mass index and abdominal fat thickness, were lower among SCD victims aged ≥ 80 years than among victims aged < 80 years. In those with IHD as etiology of SCD, at least 75% stenosis in one or more major coronary vessels was more common in SCD victims aged ≥ 80 years than among victims aged < 80 years (P =.001). SCD victims 80 years or older were less likely to die during physical activity than those under 80 years old (5.6% vs. 15.9%, P <.001). Dying in sauna was more common among those ≥ 80 years than among those < 80 years (5.5% vs. 2.6%, P <.001). Conclusion: In victims of unexpected SCD aged ≥ 80 years, the autopsy-based etiology of SCD was more commonly IHD than in those aged < 80 years. In SCD victims aged ≥ 80 years, severe fibrosis in myocardium, representing arrhythmic substrate, was more common than in the younger ones. [ABSTRACT FROM AUTHOR]
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