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Bacterial and fungal agents in house dust and wheeze in children: the PARSIFAL study.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Corporate Authors:
      PARSIFAL Study Group
    • المصدر:
      Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8906443 Publication Model: Print Cited Medium: Print ISSN: 0954-7894 (Print) Linking ISSN: 09547894 NLM ISO Abbreviation: Clin Exp Allergy Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Oxford : Blackwell Scientific Publications, c1989-
    • الموضوع:
      Agriculture*; Allergens/*analysis ; Dust/*analysis ; Respiratory Hypersensitivity/*prevention & control ; Respiratory Sounds/*etiology; Adolescent ; Air Pollution, Indoor/analysis ; Antigens, Fungal/analysis ; Beds ; Child ; Child, Preschool ; Cross-Sectional Studies ; Endotoxins/analysis ; Europe/epidemiology ; Female ; Housing ; Humans ; Inhalation Exposure/analysis ; Male ; Polysaccharides/analysis ; Respiratory Hypersensitivity/epidemiology ; Respiratory Hypersensitivity/etiology ; Schools ; beta-Glucans/analysis
    • نبذة مختصرة :
      Background: Growing up on a farm and an anthroposophic lifestyle are associated with a lower prevalence of allergic diseases in childhood. This might be related to increased inhalatory exposure to microbial agents.
      Objective: To assess the association between microbial agents in house dust and atopic wheeze in farm children, Steiner school children and reference children.
      Methods: Levels of bacterial endotoxin, fungal beta(1,3)-glucans and fungal extracellular polysaccharides (EPS) in mattress and living room floor dust were measured in a population of 270 atopic (=Phadiatop-positive) children with self-reported wheezing, including 168 current atopic wheezers, and 441 non-atopic, non-symptomatic controls. These children were selected from a cross-sectional study in five European countries.
      Results: In the study population as a whole, average levels of mattress dust endotoxin, EPS and glucans were slightly (1.1-1.2-fold; P<0.10) higher in control children than in atopic wheezers. Atopic wheeze was related to mattress levels of endotoxin, EPS and glucans in farm and farm-reference children. However, when adjusting for group (farm vs. farm-reference children), the associations became non-significant whereas the group effect remained. No associations between atopic wheeze and microbial agents were observed in Steiner and Steiner-reference children. For current atopic wheeze, the farm effect became non-significant after adjustment for microbial agent levels.
      Conclusion: Not only bacterial endotoxin but also mould components might offer some protection against atopic wheeze in children. However, the protective effect of being raised on a farm was largely unexplained by the mattress microbial agent levels measured in this study.
    • الرقم المعرف:
      0 (Allergens)
      0 (Antigens, Fungal)
      0 (Dust)
      0 (Endotoxins)
      0 (Polysaccharides)
      0 (beta-Glucans)
      9051-97-2 (beta-1,3-glucan)
    • الموضوع:
      Date Created: 20051022 Date Completed: 20060209 Latest Revision: 20070719
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1111/j.1365-2222.2005.02339.x
    • الرقم المعرف:
      16238785