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Drug therapy of dementia in elderly patients. A review.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Olsen CE;Olsen CE; Poulsen HD; Lublin HK
  • المصدر:
    Nordic journal of psychiatry [Nord J Psychiatry] 2005; Vol. 59 (2), pp. 71-7.
  • نوع النشر :
    Journal Article; Review
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 100927567 Publication Model: Print Cited Medium: Print ISSN: 0803-9488 (Print) Linking ISSN: 08039488 NLM ISO Abbreviation: Nord J Psychiatry Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: Oslo ; Boston : Scandinavian University Press, c1999-
    • الموضوع:
      Dementia/*drug therapy ; Galantamine/*therapeutic use ; Indans/*therapeutic use ; Memantine/*therapeutic use ; Neuroprotective Agents/*therapeutic use ; Phenylcarbamates/*therapeutic use ; Piperidines/*therapeutic use; Aged ; Alzheimer Disease/drug therapy ; Donepezil ; Humans ; Randomized Controlled Trials as Topic ; Rivastigmine
    • نبذة مختصرة :
      Today drug therapy of dementia in elderly patients is possible. Owing to a huge increase in the number of elderly people throughout the Western world in the coming years, evidence-based treatment of dementia in this group is needed. The article reviews double-blind, randomized trials on the effect in dementia of donepezil, galantamine, rivastigmine and memantine up to 2003. A total of 27 studies were included. Donepezil, galantamine, rivastigmine and memantine improve cognition and the global level of functioning in mild to moderate Alzheimer's disease (AD). Most evidence exists for donepezil and galantamine. The effect of rivastigmine is best documented in Lewy body dementia (LB). Galantamine, memantine and donepezil may improve cognition in vascular dementia (VD). Galantamine may improve behavioural psychological symptoms of dementia (BPSD). No solid evidence for drug therapy in severe dementia exists. Elderly patients with mild to moderate AD should be offered drug therapy. One should also consider expanding the indication of dementia treatment to LB and VD. An international consensus on what primary efficacy variables to use is needed.
    • Number of References:
      40
    • الرقم المعرف:
      0 (Indans)
      0 (Neuroprotective Agents)
      0 (Phenylcarbamates)
      0 (Piperidines)
      0D3Q044KCA (Galantamine)
      8SSC91326P (Donepezil)
      PKI06M3IW0 (Rivastigmine)
      W8O17SJF3T (Memantine)
    • الموضوع:
      Date Created: 20051001 Date Completed: 20051108 Latest Revision: 20181201
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1080/08039480510022936
    • الرقم المعرف:
      16195103