CARACTERIZAÇÃO EPIDEMIOLÓGICA DAS NEOPLASIAS DO SISTEMA NERVOSO CENTRAL EM PACIENTES DA REGIÃO NORTE DO BRASIL. (Portuguese)

EPIDEMIOLOGICAL CHARACTERIZATION OF CENTRAL NERVOUS SYSTEM TUMORS IN PATIENTS FROM NORTHERN BRAZIL. (English)

Introduction: The incidence of central nervous system (CNS) cancer has gradually increased worldwide. In Brazil, primary brain tumors are the seventh leading cause of death among malignant tumors. The objective of the present study was to characterize the epidemiological profile of patients with CNS cancer from a state in northern Brazil. Methods: This retrospective study analyzed 196 medical records between 2012 and 2016 from two hospitals in northern Brazil. Results: Glioblastoma multiforme was predominant (30.6%) among primary tumors, followed by astrocytoma (12.2%). Secondary cancer, defined as brain metastases, accounted for 29.9% of the sample and was mostly associated with lung and breast cancer. The histological severity of neoplastic lesions was more frequent in men (p = 0.01). Cancer occurred more frequently after the fourth decade of life, except in cases of astrocytoma and medulloblastoma, which mostly affected children and young adults. Conclusion: The characterization of CNS tumors is important for understanding the current situation of this public health problem in northern Brazil. [ABSTRACT FROM AUTHOR]

Introdução: A incidência de neoplasias que acometem o Sistema Nervoso Central (SNC) tem aumentado gradativamente no mundo. No Brasil, as neoplasias encefálicas primárias são classificadas como a sétima causa de morte entre as neoplasias malignas. O objetivo do presente estudo foi caracterizar o perfil epidemiológico dos pacientes acometidos por neoplasias do SNC em um estado do Norte do Brasil. Métodos: Estudo retrospectivo, onde 196 prontuários, entre 2012 e 2016, de dois hospitais na região Norte do Brasil foram analisados. Resultados: O glioblastoma multiforme foi predominante (30,6%) entre as neoplasias primárias, seguido pelo astrocitoma (12,2%). As neoplasias secundárias, identificadas como metástases encefálicas, corresponderam a 29,9% da amostra, principalmente derivadas de neoplasias do pulmão e mama. A gravidade histológica das lesões neoplásicas foi mais frequente nos homens (p = 0,01). Foi observado que as neoplasias ocorreram com maior frequência a partir da 4° década de vida, exceto nos casos de astrocitoma e meduloblastoma, que foram detectadas principalmente em crianças e adultos jovens. Conclusão: A caracterização dos casos de neoplasias do SNC é de importante para a compreensão da situação atual deste problema de saúde pública na região norte do Brasil. [ABSTRACT FROM AUTHOR]

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