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MHC microsatellite diversity and linkage disequilibrium among common HLA-A, HLA-B, DRB1 haplotypes: implications for unrelated donor hematopoietic transplantation and disease association studies.

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  • المؤلفون: Malkki M;Malkki M; Single R; Carrington M; Thomson G; Petersdorf E
  • المصدر:
    Tissue antigens [Tissue Antigens] 2005 Aug; Vol. 66 (2), pp. 114-24.
  • نوع النشر :
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Wiley Blackwell Country of Publication: England NLM ID: 0331072 Publication Model: Print Cited Medium: Print ISSN: 0001-2815 (Print) Linking ISSN: 00012815 NLM ISO Abbreviation: Tissue Antigens Subsets: MEDLINE
    • بيانات النشر:
      Publication: <2015>: [Oxford] : Wiley Blackwell
      Original Publication: 1971- : Copenhagen, Munksgaard.
    • الموضوع:
      Linkage Disequilibrium*; HLA-A Antigens/*genetics ; HLA-B Antigens/*genetics ; HLA-C Antigens/*genetics ; HLA-DQ Antigens/*genetics ; HLA-DR Antigens/*genetics ; Microsatellite Repeats/*genetics; Gene Frequency ; Genetic Variation ; HLA-DQ beta-Chains ; HLA-DRB1 Chains ; Haplotypes/genetics ; Hematopoietic Stem Cell Transplantation ; Histocompatibility Testing ; Humans
    • نبذة مختصرة :
      Twenty-two human major histocompatibility complex (MHC) region microsatellite (Msat) markers were studied for diversity and linkage disequilibrium (LD) with HLA loci in hematopoietic cell transplant recipients and their HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 allele-matched unrelated donors. These Msats showed highly significant LD over much of the MHC region. The Msat diversity of five common Caucasian haplotypes (HLA-A1-B8-DR3, A3-B7-DR15, A2-B44-DR4, A29-B44-DR7, and A2-B7-DR15) was examined using a new measure called 'haplotype specific heterozygosity' (HSH). Each of the five haplotypes had at least one Msat marker with an HSH value of zero indicating that only one Msat allele was observed for the particular HLA haplotype. In addition, the ability of Msats to predict HLA-A-B-DRB1 haplotypes was studied. Over 90% prediction probability of two common haplotypes (HLA-A1-B8-DR3 and HLA-A3-B7-DR15) was achieved with information from three Msats (D6S265/D6S2787/D6S2894 and D6S510/D6S2810/D6S2876, respectively). We demonstrate how the HSH index can be used in the selection of informative Msats for transplantation and disease association studies. Markers with low HSH values can be used to predict specific HLA haplotypes or multilocus genotypes to supplement the screening of HLA-matched donors for transplantation. Markers with high HSH values will be most informative in studies investigating MHC region disease-susceptibility genes where HLA haplotypic effects are known to exist.
    • Grant Information:
      AI33484 United States AI NIAID NIH HHS; AI49213 United States AI NIAID NIH HHS; AL49213 United States PHS HHS; CA18029 United States CA NCI NIH HHS; GM 35326 United States GM NIGMS NIH HHS; N01-CO-12400 United States CO NCI NIH HHS; P30CA22435 United States CA NCI NIH HHS
    • الرقم المعرف:
      0 (HLA-A Antigens)
      0 (HLA-B Antigens)
      0 (HLA-C Antigens)
      0 (HLA-DQ Antigens)
      0 (HLA-DQ beta-Chains)
      0 (HLA-DQB1 antigen)
      0 (HLA-DR Antigens)
      0 (HLA-DRB1 Chains)
    • الموضوع:
      Date Created: 20050721 Date Completed: 20050919 Latest Revision: 20160422
    • الموضوع:
      20240829
    • الرقم المعرف:
      10.1111/j.1399-0039.2005.00453.x
    • الرقم المعرف:
      16029431