Highly Controllable Nanoassemblies of Luminescent Gold Nanoparticles with Abnormal Disassembly‐Induced Emission Enhancement for In Vivo Imaging Applications.

Assembly‐induced emission enhancement has been widely observed for luminophors but it causes emission decrease after disassembly. The construction of unique nanoassemblies with disassembly‐induced emission enhancement (DIEE) is demanded. Herein, by taking advantages of alterable siloxane bridge crosslinking states, we report a facile strategy to fabricate water‐soluble nanoassemblies of luminescent gold nanoparticles (AuNPs) with abnormal DIEE. The fabricated AuNP nanoassemblies with dominant interparticle crosslinking showed a redshifted emission at ≈1070 nm with quantum yields (QYs) of 1.8 %. After disassembly, the nanoassemblies with increased intraparticle crosslinking exhibited a unique DIEE (>6 folds, QYs, 12 %) due to the enhanced ligand‐to‐metal charge transition. Besides, the disassembly facilitated renal clearance of AuNPs to reduce nonspecific retention in the body, opening new possibilities for designing highly emissive renal‐clearable nanostructures toward more bioapplications. [ABSTRACT FROM AUTHOR]

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