نبذة مختصرة : BACKGROUND: Neural stem cells have the effect of repairing, replacing damaged nerve cells, stimulating neurogenesis, rebuilding cell circuits, inhibiting apoptosis, and have shown a good therapeutic effect in the study of Alzheimer’s disease. Traditional Chinese medicine also has significant efficacy on regulating the proliferation and differentiation of neural stem cells and improving nerve cell viability and cell survival. OBJECTIVE: To review the mechanism of traditional Chinese medicine regulating neural stem cells in the treatment of Alzheimer’s disease, so as to provide a reference for the research and treatment of new drugs for Alzheimer’s disease. METHODS: The articles on Wanfang, CNKI, PubMed, Web of Science and other databases about neural stem cell regulated by traditional Chinese medicine in the treatment of Alzheimer’s disease from 2010 to 2022 were searched, with “neural stem cells, traditional Chinese medicine, Alzheimer’s disease” as the key words in Chinese and English. The outdated and repetitive viewpoints were excluded, and the retrieved articles were analyzed and sorted out, and a total of 121 articles were included for analysis. RESULTS AND CONCLUSION: (1) The definition and pathogenesis of neural stem cells and Alzheimer’s disease were sorted out. (2) The mechanism of action of traditional Chinese medicine in regulating neural stem cells in the treatment of Alzheimer’s disease was summarized, mainly including promoting the proliferation of neural stem cells, improving the microenvironment in the brain, inhibiting the apoptosis of nerve cells, inducing neural stem cell differentiation into neurons, improving neuroinflammation, and regulating vascular nerve units. (3) Through the existing research, the relevant factors and signaling pathways of traditional Chinese medicine to regulate neural stem cells in the treatment of Alzheimer’s disease were summarized, such as Nestin protein, microtubuleassociated protein, cerebrogenic neurotrophic factor, vascular endothelial growth factor and Notch signal pathway, P13k/Akt signaling pathway, brain-derived neurotrophic factor/TrkB signaling pathway, and Wnt/β-catenin signaling pathway. It may provide a relevant reference for the future research on new drugs for Alzheimer’s disease and new clinical treatment methods. [ABSTRACT FROM AUTHOR]
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