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Assessment of oxidative stress markers in elderly patients with SARS-CoV-2 infection and potential prognostic implications in the medium and long term.
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- المؤلفون: Vazquez-Agra, Nestor1 (AUTHOR) ; Marques-Afonso, Ana-Teresa1 (AUTHOR); Cruces-Sande, Anton2 (AUTHOR) ; Novo-Veleiro, Ignacio1 (AUTHOR); Pose-Reino, Antonio1 (AUTHOR); Mendez-Alvarez, Estefania2 (AUTHOR); Soto-Otero, Ramon2 (AUTHOR); Hermida-Ameijeiras, Alvaro1 (AUTHOR)
- المصدر:
PLoS ONE. 10/6/2022, Vol. 17 Issue 10, p1-17. 17p.
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
We aimed to evaluate the correlation of plasma levels of thiobarbituric acid reactive substances (TBARS) and reduced thiols with morbidity, mortality and immune response during and after SARS-CoV-2 infection. This was an observational study that included inpatients with SARS-CoV-2 infection older than 65 years. The individuals were followed up to the twelfth month post-discharge. Plasma levels of TBARS and reduced thiols were quantified as a measure of lipid and protein oxidation, respectively. Fatal and non-fatal events were evaluated during admission and at the third, sixth and twelfth month post-discharge. Differences in oxidative stress markers between the groups of interest, time to a negative RT-qPCR and time to significant anti-SARS-CoV-2 IgM titers were assessed. We included 61 patients (57% women) with a mean age of 83 years old. After multivariate analysis, we found differences in TBARS and reduced thiol levels between the comparison groups in fatal and non-fatal events during hospital admission. TBARS levels were also correlated with fatal events at the 6th and 12th months post-discharge. One year after hospital discharge, other predictors rather than oxidative stress markers were relevant in the models. The median time to reach significant anti-SARS-CoV-2 IgM titers was lower in patients with low levels of reduced thiols. Assessment of some parameters related to oxidative stress may help identify groups of patients with a higher risk of morbidity, mortality and delayed immune response during and after SARS-CoV-2 infection. [ABSTRACT FROM AUTHOR]
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