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Low rate of SARS-CoV-2 incident infection identified by weekly screening PCR in a prospective year-long cohort study.
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- المؤلفون: Harrington, Whitney E.1,2 (AUTHOR); Yeung, Winnie1 (AUTHOR); Beck, Ingrid A.1 (AUTHOR); Mast, Fred D.1 (AUTHOR); Houck, John1 (AUTHOR); Styrchak, Sheila1 (AUTHOR); Miller, Leslie R.1 (AUTHOR); Li, Song1 (AUTHOR); Haglund, Micaela1 (AUTHOR); Jiang, Yonghou1 (AUTHOR); Armistead, Blair1 (AUTHOR); Wallner, Jackson1 (AUTHOR); Nguyen, Tina1 (AUTHOR); Ko, Daisy1 (AUTHOR); Hardy, Samantha1 (AUTHOR); Oldroyd, Alyssa1 (AUTHOR); Gervassi, Ana1 (AUTHOR); Aitchison, John D.1,2,3 (AUTHOR); Frenkel, Lisa M.1,2 (AUTHOR)
- المصدر:
PLoS ONE. 9/26/2022, Vol. 17 Issue 9, p1-8. 8p.
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
Background: Asymptomatic and pre-symptomatic SARS-CoV-2 infections may contribute to ongoing community transmission, however, the benefit of routine screening of asymptomatic individuals in low-risk populations is unclear. Methods: To identify SARS-CoV-2 infections 553 seronegative individuals were prospectively followed for 52 weeks. From 4/2020-7/2021, participants submitted weekly self-collected nasal swabs for rtPCR and completed symptom and exposure surveys. Results: Incident SARS2-CoV-2 infections were identified in 9/553 (1.6%) participants. Comparisons of SARS2-CoV-2(+) to SARS2-CoV-2(-) participants revealed significantly more close contacts outside the household (median: 5 versus 3; p = 0.005). The incidence of infection was higher among unvaccinated/partially vaccinated than among fully vaccinated participants (9/7,679 versus 0/6,845 person-weeks; p = 0.004). At notification of positive test result, eight cases were symptomatic and one pre-symptomatic. Conclusions: These data suggest that weekly SARS2-CoV2 surveillance by rtPCR did not efficiently detect pre-symptomatic infections in unvaccinated participants. [ABSTRACT FROM AUTHOR]
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