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Functional analysis of AeSCP-2 using gene expression knockdown in the yellow fever mosquito, Aedes aegypti.

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  • المؤلفون: Blitzer EJ;Blitzer EJ; Vyazunova I; Lan Q
  • المصدر:
    Insect molecular biology [Insect Mol Biol] 2005 Jun; Vol. 14 (3), pp. 301-7.
  • نوع النشر :
    Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Blackwell Scientific For The Royal Entomological Society Country of Publication: England NLM ID: 9303579 Publication Model: Print Cited Medium: Print ISSN: 0962-1075 (Print) Linking ISSN: 09621075 NLM ISO Abbreviation: Insect Mol Biol Subsets: MEDLINE
    • بيانات النشر:
      Publication: Oxford : Blackwell Scientific For The Royal Entomological Society
      Original Publication: Oxford : Published for the Royal Entomological Society by Blackwell Scientific Publications, c1992-
    • الموضوع:
      Aedes/*physiology ; Carrier Proteins/*physiology ; Insect Proteins/*physiology; Aedes/genetics ; Aedes/metabolism ; Animals ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cholesterol/metabolism ; Gene Silencing ; Insect Proteins/genetics ; Insect Proteins/metabolism ; Larva/metabolism ; Mutation ; Ovum ; Pupa/metabolism ; Reproduction
    • نبذة مختصرة :
      The effect of gene expression knockdown was used to study the function of the sterol carrier protein-2 (AeSCP-2) in the yellow fever mosquito, Aedes aegypti. Injection of small double stranded AeSCP-2 RNAs into mosquito larvae resulted in the knockdown of gene products. The lack of AeSCP-2 in larvae coincided with a reduction in accumulated cholesterol in pupae, supporting the hypothesis that AeSCP-2 may be involved in cholesterol uptake in mosquito larvae. Knockdown of AeSCP-2 caused a high mortality rate in developing adult and reduced egg viability. Results from this study indicate that AeSCP-2 is important for adult development and for the viability of the eggs.
    • الرقم المعرف:
      0 (Carrier Proteins)
      0 (Insect Proteins)
      0 (sterol carrier proteins)
      97C5T2UQ7J (Cholesterol)
    • الموضوع:
      Date Created: 20050602 Date Completed: 20050708 Latest Revision: 20131121
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.1111/j.1365-2583.2005.00560.x
    • الرقم المعرف:
      15926899