MAMMARY ADENOMA ASSOCIATED WITH CHRONIC MASTITIS IN A WILD BOAR (SUS SCROFA).

ADENOM MLEČNE ŽLEZDE POVEZAN SA HRONIČNIM MASTITISOM KOD DIVLJE SVINJE (SUS SCROFA).

Mammary gland tumor is rare and only a few cases have been reported in wild animals. Moreover, most etiologies of the known cases in veterinary medicine are related to age, diet, obesity, and excessive sex hormones in domestic animals while few etiologies are reported in wild animals. An unknown-aged female wild boar was presented to the Department of Veterinary Pathology, Kyungpook National University with a well-demarcated, and firm-to-elastic mammary gland mass. The cut-surface of the mass was pink-reddish, and homogeneous. Microscopically, the mass was mainly composed of well-differentiated neoplastic glandular epithelial cells characterized by a single-layer, columnar to cuboidal shapes, and small and central nuclei and nucleoli. Any evidence of invasiveness or metastases of the neoplastic cells were not observed. Interestingly, infiltration of chronic inflammatory cells such as plasma cells and macrophages was observed along with a large quantity of gram-negative and positive bacterial colonies in the mammary glands. Moreover, accompanied fibrosis of stroma was observed, as well. Based on the gross and microscopic findings, the present case was diagnosed as mammary simple adenoma caused by chronic mastitis progressing to fibrotic condition. To the authors' knowledge, this is the first study describing the histopathological aspects of mammary gland tumors associated with chronic mastitis accompanied by fibrosis in wild animals. [ABSTRACT FROM AUTHOR]

Kod divljih životinja, tumori mlečne žlezde se retko nalaze i opisuju u literaturi. Kod domaćih vrsta životinja kod opisanih slučajeva, većinom su povezani sa starošću, načinom i kvalitetom ishrane, gojaznošću i sa velikim koncentracijama polnih hormona međutim, kod divljih vrsta životinja nema podataka o etiologiji ovog oboljenja. Na Departmanu za veterinarsku patologiju, Kyungpook nacionalnog Univerziteta, dopremljena je divlja svinje nepoznate starosti, kod koje su uočene dobro demarkirane čvrste do elastične mase u mlečnoj žlezdi. Površina preseka novotvorevine bila je ljubičasto-crvene boje i homogene strukture. Mikroskopskim pregledom uočeno je da se masa uglavnom sastojala iz dobro diferenciranih neoplastičnih glandularnih epitelnih jednoslojnih ćelija, peharastog do kuboidnog oblika sa centralno položenim malim jedrima i jedarcima. Nisu uočene bilo kakve invazivne osobine ili metastaze neoplastičnih ćelija. Interesantan je nalaz infiltracije hroničnih zapaljenskih ćelija kao što su plazma ćelije i makrofagi zajedno sa nalazom brojnih kolonija gram negativnih i gram pozitivnih bakterija u mlečnoj žlezdi. Isto tako, pored ovog nalaza, uočena je i fibroza strome. Na osnovu makroskopskih i mikroskopskih promena, postavljena je dijagnoza: jednostavni adenom mlečne žlezde izazvan hroničnim mastitisom koji je progredirao u stanje fibroze. Prema saznanju autora, radi se o prvoj studiji kojom se opisuju histopatološki aspekti tumora mlečne žlezde povezanim sa hroničnim mastitisom koji je praćen fibrozom, kod divljih životinja. [ABSTRACT FROM AUTHOR]