CNS TB-IRIS Following Cessation of Adalimumab in an Adolescent With Crohn's Disease.

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المؤلفون: Christian, Elizabeth^1,2 (AUTHOR) ; Johnston, Alicia¹ (AUTHOR)
المصدر:
Open Forum Infectious Diseases. Aug2022, Vol. 9 Issue 8, p1-5. 5p.
الموضوع:
*IMMUNE reconstitution inflammatory syndrome; *CROHN'S disease; *TUMOR necrosis factors; *CENTRAL nervous system; *ADALIMUMAB

معلومة اضافية
- نبذة مختصرة :
  Immune reconstitution inflammatory syndrome to tuberculosis (TB-IRIS) is an inflammatory response to M. tuberculosis infection that arises following restoration of the immune system and is increasingly recognized as a risk in patients treated with tumor necrosis factor α inhibitors who develop active tuberculosis infection. We present the case of a 19-year-old man treated with adalimumab for Crohn's disease who presented with disseminated miliary tuberculosis. His treatment course was complicated by central nervous system TB-IRIS following cessation of his immunosuppression. We review the presentation and differential diagnosis of TB-IRIS, as well as risk factors for developing IRIS and the treatment of IRIS in this population. [ABSTRACT FROM AUTHOR]