Severe vaccine‐acquired rotavirus infection in an infant with primary intestinal lymphangiectasia.

We describe the first case of a previously asymptomatic infant who developed a severe vaccine-acquired rotavirus infection after receiving the first Rotarix dose, associating lymphopenia and hypoalbuminemia. The high similarity to the Rotarix vaccine strain and the failure to detect other common enteric pathogens reassure the likelihood of infection caused by the vaccine-derived strain. Keywords: attenuated vaccine; intestinal lymphangiectasis; rotavirus EN attenuated vaccine intestinal lymphangiectasis rotavirus 1 4 4 08/29/22 20220801 NES 220801 Key Message To date, severe cases of vaccine-related rotavirus infection have only been reported in infants with severe combined immunodeficiency after immunization. [Extracted from the article]

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