- Alternate Title:
The Relationship Between Laboratory Findings and Bone Mineral Density in Patients with Osteoporosis. (English)
- نبذة مختصرة :
Objective: This study was conducted to investigate the relationship between platelet count, mean platelet volume (MPV), platelet distribution width (PDW), C-reactive protein (CRP), platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), systemic immune-inflammation index (SII) and osteoporosis (OP) in postmenopausal women. Materials and Methods: Four hundred eighty two patients who had been in menopause for at least 2 years were included in our study. Hemogram, CRP, thyroid-stimulating hormone (TSH), parathyroid hormone, 25-hydroxyvitamin D3 vitamin and dual-energy X-ray absorptiometry results of all patients were recorded. Two hundred ninety five patients with L2-L4 and/or femoral neck T-scores ≤-2.5 were determined as the OP group, and 192 patients with L2-L4 and/or Femoral neck T-scores ≥-1.0 were determined as the control group. NLR, PLR and SII were calculated and recorded from the hemogram results. Results: The mean age of the OP group was 64.2±8.3 years, and the mean age of the control group was 56.6±8.7. Age and vitamin D3 levels were higher in the OP group than in the control group (p<0.001). Leukocytes, neutrophil and MPV levels were found to be lower in the OP group than in the control group (p<0.005). While the L2-L4 T-score was negatively correlated with age and vitamin D3; leukocytes, MPV, PDW, TSH and CRP were positively correlated. The femoral neck T-score was negatively correlated with age and vitamin D3, whereas it was positively correlated with MPV, PDW, TSH and CRP. Conclusion: Platelet functions and immune system markers are effective in bone mineralization in postmenopausal OP patients. [ABSTRACT FROM AUTHOR]
- نبذة مختصرة :
Amaç: Bu çalışma, Postmenopozal kadınlarda trombosit sayısı, ortalama trombosit hacmi (MPV), trombosit dağılım genişliği (PDW), C-reaktif protein (CRP), trombosit/lenfosit oranı (TLO), nötrofil/lenfosit oranı (NLO) ve sistemik immün-enflamasyon indeksi (SII) ile osteoporoz (OP) arasındaki ilişkiyi araştırmak amacıyla yapılmıştır. Gereç ve Yöntem: Çalışmamıza en az 2 yıldır menopoza girmiş 482 hasta dahil edildi. Tüm hastaların hemogram, CRP, tiroid stimülan hormon (TSH), paratiroid hormon, 25-hydroksivitamin D3 vitamini ve dual enerji X-ışını absorbsiyometri sonuçları kaydedildi. L2-L4 ve/veya Femur boynu T-skoru ≤-2,5 olan 295 hasta OP grubu olarak, L2-L4 ve/veya Femur boynu T-skoru ≥-1,0 olan 192 hasta ise kontrol grubu olarak belirlendi. Hemogram sonucundan NLO, TLO ve SII hesaplanarak kaydedildi. Bulgular: OP grubunun yaş ortalaması 64,2±8,3, kontrol grubunun yaş ortalaması 56,6±8,7 idi. Yaş ve vitamin D3 seviyeleri OP grubunda kontrol grubuna göre anlamlı düzeyde yüksek bulundu (p<0,001). OP olan grupta lökosit, nötrofil ve MPV düzeyleri kontrol grubuna göre anlamlı şekilde düşük saptandı (p<0,005). Diğer laboratuvar parametrelerinde gruplar arasında anlamlı farklılık yoktu. Yapılan korelasyon analizine göre, L2-L4 T-skoru ile yaş ve vitamin D3 negatif korele iken; lökosit, MPV, PDW, TSH ve CRP pozitif korele idi. Femur boynu T-skoru ile yaş ve vitamin D3 negatif korelasyon gösterirken; MPV, PDW, TSH ve CRP pozitif korelasyon gösterdi. Sonuç: Postmenopozal OP hastalarında trombosit fonksiyonları ve immün sistem belirteçleri kemik mineralizasyonunda etkilidir. [ABSTRACT FROM AUTHOR]
- نبذة مختصرة :
Copyright of Turkish Journal of Osteoporosis / Turk Osteoporoz Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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