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Epidemiologic, Clinical, and Genetic Characteristics of Human Infections with Influenza A(H5N6) Viruses, China.
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- المؤلفون: Wenfei Zhu1,2,3; Xiyan Li1,2,3; Jie Dong1,2,3; Hong Bo1,2,3; Jia Liu1,2,3; Jiaying Yang1,2,3; Ye Zhang1,2,3; Hejiang Wei1,2,3; Weijuan Huang1,2,3; Xiang Zhao1,2,3; Tao Chen1,2,3; Jing Yang1,2,3,4; Zi Li1,2,3; Xiaoxu Zeng1,2,3; Chao Li5; Jing Tang1,2,3; Li Xin1,2,3; Rongbao Gao1,2,3; Liqi Liu1,2,3; Min Tan1,2,3
- المصدر:
Emerging Infectious Diseases. Jul2022, Vol. 28 Issue 7, p1332-1344. 13p.
- الموضوع:
- معلومة اضافية
- الموضوع:
- نبذة مختصرة :
The recent rise in the frequency of influenza A(H5N6) infections in China has raised serious concerns about whether the risk for human infection has increased. We surveyed epidemiologic, clinical, and genetic data of human infections with A(H5N6) viruses. Severe disease occurred in 93.8% of cases, and the fatality rate was 55.4%. Median patient age was 51 years. Most H5N6 hemagglutinin (HA) genes in human isolates in 2021 originated from subclade 2.3.4.4b; we estimated the time to most recent common ancestor as June 16, 2020. A total of 13 genotypes with HA genes from multiple subclades in clade 2.3.4.4 were identified in human isolates. Of note, 4 new genotypes detected in 2021 were the major causes of increased H5N6 virus infections. Mammalian-adapted mutations were found in HA and internal genes. Although we found no evidence of human-to-human transmission, continuous evolution of H5N6 viruses may increase the risk for human infections. [ABSTRACT FROM AUTHOR]
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