Potential role of chitosan, PLGA and iron oxide nanoparticles in Parkinson's disease therapy.

Background: Parkinson's disease (PD) is a debilitating disease that alters an individual's functionality. Parkinsonism is a complex symptom consisting of numerous motor and non-motor features, and although several disorders are responsible, PD remains the most important. Several theories have been proposed for the characteristic pathological changes, the most important of which is the loss of dopaminergic neurons associated with a reduced ability to perform voluntary movements. Many drugs have been developed over the years to treat the condition and prevent its progression, but drug delivery is still a challenge due to the blood–brain barrier, which prevents the passage of drugs into the central nervous system. However, with the advances in nanotechnology in the medical field, there is growing hope of overcoming this challenge. Summary: Our review highlights the potential role of three commonly studied nanoparticles in laboratory-induced animal models of PD: chitosan, PLGA, and iron oxide nanoparticles as potential PD therapy in humans. [ABSTRACT FROM AUTHOR]

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