Antithetical effects of hemicellulase-treated Agaricus blazei on the maturation of murine bone-marrow-derived dendritic cells.

Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0374672 Publication Model: Print Cited Medium: Print ISSN: 0019-2805 (Print) Linking ISSN: 00192805 NLM ISO Abbreviation: Immunology Subsets: MEDLINE

Original Publication: Oxford : Blackwell Scientific Publications

Agaricus/*immunology ; Antigens, Fungal/*immunology ; Dendritic Cells/*immunology; Agaricus/drug effects ; Animals ; Antigens, Surface/metabolism ; Bone Marrow Cells/immunology ; Cell Differentiation/immunology ; Cell Division/immunology ; Cells, Cultured ; Cytokines/metabolism ; Glycoside Hydrolases/pharmacology ; Immune Tolerance ; Lipopolysaccharides/immunology ; Lymphocyte Activation/immunology ; Macrophages/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Ovalbumin/immunology ; T-Lymphocytes/immunology ; Th1 Cells/immunology ; Up-Regulation/immunology

We report the effects of hemicellulase-treated Agaricus blazei (ABH) on the maturation of bone-marrow-derived dendritic cells (BMDCs). ABH activated immature BMDCs, inducing up-regulation of surface molecules, such as CD40, CD80 and major histocompatibility complex class I antigens, as well as inducing allogeneic T-cell proliferation and T helper type 1 cell development. However, unlike lipopolysaccharide (LPS), ABH did not stimulate the BMDCs to produce proinflammatory cytokines, such as interleukin-12 (IL-12) p40, tumour necrosis factor-alpha, or IL-1beta. In addition, ABH suppressed LPS-induced DC responses. Pretreatment of DCs with ABH markedly reduced the levels of LPS-induced cytokine secretion, while only slightly decreasing up-regulation of the surface molecules involved in maturation. ABH also had a significant impact on peptidoglycan-induced or CpG oligodeoxynucleotide-induced IL-12p40 production in DCs. The inhibition of LPS-induced responses was not associated with a cytotoxic effect of ABH nor with an anti-inflammatory effect of IL-10. However, ABH decreased NF-kappaB-induced reporter gene expression in LPS-stimulated J774.1 cells. Interestingly, DCs preincubated with ABH and then stimulated with LPS augmented T helper type 1 responses in culture with allogeneic T cells as compared to LPS-stimulated but non-ABH-pretreated DCs. These observations suggest that ABH regulates DC-mediated responses.

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0 (Antigens, Fungal)
0 (Antigens, Surface)
0 (Cytokines)
0 (Lipopolysaccharides)
0 (NF-kappa B)
9006-59-1 (Ovalbumin)
EC 3.2.1.- (Glycoside Hydrolases)
EC 3.2.1.- (hemicellulase)

Date Created: 20050222 Date Completed: 20050412 Latest Revision: 20181113

20221213

PMC1782089

10.1111/j.1365-2567.2004.02106.x

15720441