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The common sense of the self-nonself discrimination.

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  • المؤلفون: Cohn M;Cohn M
  • المصدر:
    Springer seminars in immunopathology [Springer Semin Immunopathol] 2005 Jun; Vol. 27 (1), pp. 3-17. Date of Electronic Publication: 2005 Feb 15.
  • نوع النشر :
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Springer International Country of Publication: Germany NLM ID: 7910384 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0344-4325 (Print) Linking ISSN: 03444325 NLM ISO Abbreviation: Springer Semin Immunopathol Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Berlin, New York, Springer International.
    • الموضوع:
      Immune System/*immunology ; Self Tolerance/*immunology; Animals ; Humans ; Neoplasms/immunology ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Helper-Inducer/immunology
    • نبذة مختصرة :
      The vertebrate immune system was evolutionarily selected to express a large random somatically generated paratopic repertoire coupled to effector mechanisms invented, in large measure, by non-vertebrates. The self-nonself discrimination is determined by Decision 1, the sorting of this repertoire into those specificities (anti-self) which, if expressed, would debilitate the host and those specificities (anti-nonself) which, if not expressed, would result in the death of the host by infection. Decision 1, the sorting of the repertoire, is mediated by a somatic learning process operating epitope-by-epitope that deletes anti-self specificities leaving the residue as anti-nonself. The activation of anti-nonself is the first step on entry into Decision 2, which optimizes the choice and magnitude of the effector class that rids the pathogen without significantly debilitating the host. The principles governing Decision 1, the self-nonself discrimination are analyzed here.
    • Number of References:
      31
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    • Grant Information:
      RR07716 United States RR NCRR NIH HHS
    • الموضوع:
      Date Created: 20050216 Date Completed: 20051122 Latest Revision: 20181113
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.1007/s00281-005-0199-1
    • الرقم المعرف:
      15711952