Analisis Interaksi Obat Hiperlipidemia pada Pasien PT. Pertamina di Salah Satu Apotek Kimia Farma di Bandung. (Indonesian)

Hyperlipidemia is an abnormal lipid metabolism disorder that is distinguished by an escalation of lipid levels in the blood. Hyperlipidemia is often accompanied by other diseases. Therefore, treatment of hyperlipidemia is often used in unification with other antidotes, which can increase the occurrence of antidote relationships. A bidder relationship is a state in which a substance or bidder's activity is capable of manifesting a peaking or diminishing effect or a new effect. The purpose of this research is to understand whether there is an interaction of hyperlipidemic drugs in Pertamina patients at one of Kimia Farma Pharmacies in Bandung City based on the number of patients, number of cases, interaction mechanism and severity. This research uses a nonexperimental descriptive research type approach by collecting data retrospectively based on prescription data during March 2021, with a sample of 87 prescriptions that meet the inclusion criteria. Data were analyzed descriptively using Stockley's Handbook of Drug Interactions literature. Of patients with hyperlipidemia, who have the potential to experience drug interactions as many as 28 Prescriptions. Based on the results of the research, it was found that the severity level of drug interaction cases which stated the severity level of major interactions was 1%, Moderate was 30% and minor was 1% while those that did not interact were 68%. Based on the research results above, the researchers summarized that there were 28 cases of prescription sheets containing hyperlipidemia drug interactions in March 2021 at Kimia Farma Pharmacy. The level of drug interactions consisted of major, moderate and minor categories with a severity level of 1% for the major category, 30% for the moderate category, 1% for the minor category, while 68% had no interactions. [ABSTRACT FROM AUTHOR]

Hiperlipidemia adalah gangguan metabolisme lipid abnormal yang dibedakan atas eskalasi takaran lipid dalam darah. Hiperlipidemia sering disertai dengan penyakit lain. Oleh karena itu, pengobatan hiperlipidemia sering dipakai dalam unifikasi dengan penawar lain, yang mampu meninggikan terjadinya hubungan penawar. Hubungan penawar merupakan keadaan di saat suatu zat atau kegiatan penawar mampu memanifestasikan dampak yang memuncak atau menyusut atau dampak baru. Maksud dari riset ini adalah untuk memahami ada tidaknya interaksi obat hiperlipidemia pada pasien Pertamina di salah satu Apotik Kimia Farma Kota Bandung beralaskan jumlah pasien, jumlah kasus, mekanisme interaksi dan tingkat keparahan. Riset ini menggunakan pendekatan tipe riset deskriptif non-eksperimental dengan mengumpulkan data secara retrospektif beralaskan data resep selama bulan Maret 2021, dengan jumlah sampel 87 resep yang memenuhi kriteria inklusi. Data dianalisis secara deskriptif dengan menggunakan literatur Buku Pegangan Interaksi Obat Stockley. Dari pasien hiperlipidemia, yang berpotensi mengalami interaksi obat sebesesar 28 Resep. Beralaskan hasil riset yang didapati bahwa level keparahan kasus interaksi obat yang menyatakan level keparahan interaksi mayor sebesar 1%, Moderat sebesar 30% dan minor sebanyak 1% sedangkan yang tidak berinteraksi sebanyak 68%. Beralaskan hasil riset di atas, peneliti mengikhtisarkan bahwa lembar resep yang memuat terjadinya interaksi obat hiperlipidemia pada bulan Maret 2021 di Apotek Kimia Farma sebanyak 28 kasus. Tingkatan pada interaksi obat terdiri dari kategori mayor, moderat dan minor dengan tingkat keparahan sebesar 1% untuk kategori mayor, 30% untuk kategori moderat, 1% untuk kategori minor, sementara yang 68% tidak ada interaksi. [ABSTRACT FROM AUTHOR]

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