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An Untargeted LC–MS based approach for identification of altered metabolites in blood plasma of rheumatic heart disease patients.
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- المؤلفون: Das, Soumi; Kumar, Yashwant; Sharma, Shruti; Ray, Ruma; Arava, Sudheer; Seth, Sandeep; Agarwal, Aman; Sharma, Gautam
- المصدر:
Scientific Reports; 3/28/2022, Vol. 12 Issue 1, p1-7, 7p
- الموضوع:
- معلومة اضافية
- الموضوع:
- نبذة مختصرة :
Rheumatic heart disease (RHD) is often considered as a disease of developing countries and India is the home of about 40% of RHD patients. Environment seems to play a major role in its causation. Since gene environment interactions can lead to alterations of various metabolic pathways, identification of altered metabolites can help in understanding the various pathways leading to RHD. Blood plasma samples from 51 RHD and 49 healthy controls were collected for the study. Untargeted metabolomics approach was used to identify the metabolites that are altered in RHD patients. Data showed 25 altered metabolites among RHD patients. These altered metabolites were those involved in Purine, Glutamine, Glutamate, Pyrimidine, Arginine, Proline and Linoleic metabolism. Thus, the present study illuminates metabolic alterations among RHD patients which can help in determining the potential therapeutic targets. [ABSTRACT FROM AUTHOR]
- نبذة مختصرة :
Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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