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The Salmonella SPI1 effector SopB stimulates nitric oxide production long after invasion.

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  • معلومة اضافية
    • المصدر:
      Publisher: Hindawi Country of Publication: India NLM ID: 100883691 Publication Model: Print Cited Medium: Print ISSN: 1462-5814 (Print) Linking ISSN: 14625814 NLM ISO Abbreviation: Cell Microbiol Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2022- : Mumbai : Hindawi
      Original Publication: Oxford : Wiley-Blackwell, c1999-
    • الموضوع:
      Bacterial Proteins/*physiology ; Macrophages/*microbiology ; Nitric Oxide/*biosynthesis ; Salmonella enterica/*physiology; Animals ; Bacterial Proteins/genetics ; Cells, Cultured ; Genomic Islands/genetics ; Genomic Islands/physiology ; Macrophages/immunology ; Mice ; Nitric Oxide/analysis ; Nitric Oxide Synthase/analysis ; Nitric Oxide Synthase/biosynthesis ; Nitric Oxide Synthase Type II ; RNA, Bacterial/analysis ; RNA, Messenger/analysis
    • نبذة مختصرة :
      The ability of Salmonella enterica to invade and replicate within host cells depends on two type III secretion systems (TTSSs) encoded on pathogenicity islands 1 and 2 (SPI1 and SPI2). The current paradigm holds that these systems translocate two classes of effectors that operate sequentially and independently. In essence, the SPI1 TTSS mediates early events (i.e. invasion) whereas the SPI2 TTSS mediates post-invasion processes (i.e. replication, vacuole maturation). Contrary to this model, we have found in infected macrophages that a SPI1 effector, SopB/SigD, increased inducible nitric oxide synthase levels and nitric oxide production, host cell process previously known only to be a target of the SPI2 TTSS. Furthermore, SopB protein and message persist many hours after invasion. Our findings reveal an unanticipated potential for dialogue between the SPI1 and SPI2 TTSS and the host cell response.
    • الرقم المعرف:
      0 (Bacterial Proteins)
      0 (RNA, Bacterial)
      0 (RNA, Messenger)
      31C4KY9ESH (Nitric Oxide)
      EC 1.14.13.39 (Nitric Oxide Synthase)
      EC 1.14.13.39 (Nitric Oxide Synthase Type II)
      EC 1.14.13.39 (Nos2 protein, mouse)
      EC 3.4.- (SopB protein, Salmonella)
    • الموضوع:
      Date Created: 20041225 Date Completed: 20050711 Latest Revision: 20131121
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.1111/j.1462-5822.2004.00436.x
    • الرقم المعرف:
      15617527