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Lactation in large litters influences anxiety, memory, and spreading depression in adult male rats that were chronically subjected to a non-convulsive pilocarpine dose.
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- المؤلفون: Benevides, Regina de Deus Lira1 (AUTHOR) ; de-Lima, Suênia Marcele Vitor1 (AUTHOR); Chagas, Camila Lima1 (AUTHOR); de Lima, Clara Farah1 (AUTHOR); Abadie-Guedes, Ricardo2 (AUTHOR); Guedes, Rubem Carlos Araujo1 (AUTHOR)
- المصدر:
Nutritional Neuroscience. Apr2022, Vol. 25 Issue 4, p846-856. 11p. 1 Diagram, 2 Charts, 4 Graphs.
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
Objectives: Unfavorable lactation influences brain excitability and behavioral reactions in adults. Administration early in life of the cholinergic agonist, pilocarpine, even at non-convulsive doses, alters the brain excitability-related phenomenon known as cortical spreading depression (CSD), and produce anxiogenic-like behavior. However, the influence of unfavorable lactation on the CSD- and memory-effects of pilocarpine administration late in life has not been investigated. Herein, we analyzed the ponderal, electrophysiological (CSD), and behavioral effects of chronic treatment with a non-convulsive dose of pilocarpine, in adult rats suckled under favorable and unfavorable conditions. Methods: Wistar rats were suckled in litters with 9 or 15 pups (groups L9 and L15, respectively). A very low dose of pilocarpine (45/mg/kg/day) was chronically administered in mature rats from postnatal day (PND) 69–90. Behavioral tests occurred at PND91 [elevated plus maze (EPM)], PND93 [open field (OF)], and PND94–95 [object recognition memory (ORM)]. CSD was recorded between PND96–120. Results: Pilocarpine-treated rats performed worse in the anxiety and memory tests, and displayed lower CSD propagation velocity when compared with saline-treated controls. In addition, L15 rats showed an increase in the distance traveled and a decrease in the immobility time in the EPM, impaired ORM, and accelerated CSD propagation when compared with L9 rats (p ≤ 0.05). Discussion: These data suggest that sub-convulsive pilocarpine treatment in adult rats can affect behavioral and excitability-related reactions. In addition, unfavorable lactation increases the ambulatory effects of pilocarpine. Further studies should investigate the possible cholinergic molecular mechanisms involved in these effects. [ABSTRACT FROM AUTHOR]
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