A combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9302235 Publication Model: Print Cited Medium: Print ISSN: 1018-4813 (Print) Linking ISSN: 10184813 NLM ISO Abbreviation: Eur J Hum Genet Subsets: MEDLINE

Publication: <2003->: London : Nature Publishing Group
Original Publication: Basel ; New York : Karger, [1992-

DNA, Mitochondrial/*genetics ; Longevity/*genetics ; Polymorphism, Single Nucleotide/*genetics; Aged ; Aged, 80 and over ; Epistasis, Genetic ; Female ; Finland ; Haplotypes/genetics ; Humans ; Japan ; Male ; Middle Aged ; Quantitative Trait Loci/genetics

Mitochondrial DNA (mtDNA) coding region polymorphisms, as well as the 150T polymorphism in the noncoding region, have been associated with longevity. We have studied here the association of 150T with longevity further and assessed differences in this association between various mtDNA haplogroups. We analysed a sample of 321 very old subjects and 489 middle-aged controls from Finland and Japan. 150T was more frequent among the very old than among the controls in both the Finnish and Japanese subjects. Interestingly, the association was not similar in all haplogroups, and a stratified analysis revealed that two additional common polymorphisms, 489C and 10398G, modified the association between 150T and longevity. These findings suggest that longevity is partly determined by epistatic interactions involving these three mtDNA loci.

0 (DNA, Mitochondrial)

Date Created: 20041016 Date Completed: 20050705 Latest Revision: 20061115

20240829

10.1038/sj.ejhg.5201308

15483642