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Serotype Replacement after Introduction of 10-Valent and 13-Valent Pneumococcal Conjugate Vaccines in 10 Countries, Europe.
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- المؤلفون: Hanquet, Germaine1,2 ; Krizova, Pavla3; Dalby, Tina4; Ladhani, Shamez N.5; Nuorti, J. Pekka6,7; Danis, Kostas8; Mereckiene, Jolita9; Knol, Mirjam J.10; Winje, Brita A.11; Ciruela, Pilar12,13; de Miguel, Sara14; Eugenia Portillo, Maria15; MacDonald, Laura16; Morfeldt, Eva17; Kozakova, Jana3; Valentiner-Branth, Palle4; Fry, Norman K.5; Rinta-Kokko, Hanna7; Varon, Emmanuelle18; Corcoran, Mary19
- المصدر:
Emerging Infectious Diseases. Jan2022, Vol. 28 Issue 1, p127-138. 12p. 4 Charts, 3 Graphs.
- الموضوع:
- معلومة اضافية
- الموضوع:
- نبذة مختصرة :
We evaluated invasive pneumococcal disease (IPD) during 8 years of infant pneumococcal conjugate vaccine (PCV) programs using 10-valent (PCV10) and 13-valent (PCV13) vaccines in 10 countries in Europe. IPD incidence declined during 2011-2014 but increased during 2015-2018 in all age groups. From the 7-valent PCV period to 2018, IPD incidence declined by 42% in children <5 years of age, 32% in persons 5-64 years of age, and 7% in persons >65 years of age; non-PCV13 serotype incidence increased by 111%, 63%, and 84%, respectively, for these groups. Trends were similar in countries using PCV13 or PCV10, despite different serotype distribution. In 2018, serotypes in the 15-valent and 20-valent PCVs represented one third of cases in children <5 years of age and two thirds of cases in persons >65 years of age. Non-PCV13 serotype increases reduced the overall effect of childhood PCV10/PCV13 programs on IPD. New vaccines providing broader serotype protection are needed. [ABSTRACT FROM AUTHOR]
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