Caractéristiques épidémiologiques, cliniques, thérapeutiques et évolutives des patients atteints de glioblastome cérébral: série de cas pris en charge au centre d´oncohématologie du Centre Hospitalier Universitaire Mohammed VI de Marrakech en 2016 et 2017.

Epidemiological, clinical, therapeutic and evolutionary features of patients with glioblastoma: series of cases managed in the Department of Hematology-Oncology at the Mohammed VI University Hospital Center in Marrakech in 2016 and 2017.

Glioblastoma is the most common primary malignant brain tumour. Despite advances in diagnostic and therapeutic treatments, it is still associated with poor outcome The purpose of this study of cases is to describe the epidemiological, clinical, therapeutic and evolutionary features of patients with glioblastoma admitted to the Department of Hematology-Oncology (DHO) in Marrakech in 2016 and 2017. We conducted a literature review of epidemiological, clinical, radiological, anatomopathological, therapeutic and evolutionary data from 40 patients. Glioblastoma accounted for 47.6% of treated intracranial tumours. The average age of patients was 52.4±12.3 years. Functional impotence and signs of intracranial hypertension were the main symptoms. Tumours mainly occurred in the parietal region (44%) and were large (57.5%). Aphasia was related to tumour size (p=0.042). Nine cases had glioblastomas-IDH1-wild and one case had glioblastoma-IDH1-mutant. On admission, patients had poor performance-status. This was due to a prolonged time between surgery and DHO admission (p= 0.034). Patients with sensory impairments were older (62.5±3 years) than those without sensory impairments (51.2±12 years) (p=0,045). In-patient women received chemoradiotherapy (1.5±1 month) earlier than men (2.3±1.2 months) (p=0.03). Survival was 13.6±5.3 months; it was unrelated to the time to surgery (p=0.076), the time to DHO (p=0.058), and the time to chemoradiotherapy (p=0.073). The epidemiological, clinical, radiological and evolutionary features of our sample were comparable to literature data. The molecular profiling was not systematically realized. Despite prolonged treatment times, no link to survival was detected. [ABSTRACT FROM AUTHOR]

Le glioblastome est la tumeur cérébrale maligne primaire la plus commune. Malgré les avancées diagnostico-thérapeutiques, il continue d´être de mauvais pronostic. Nous avons étudié une série de cas pour décrire les caractéristiques épidémiologiques, cliniques, thérapeutiques et évolutives des patients atteints de glioblastome admis en 2016 et 2017 au centre d´oncohématologie (COH) à Marrakech. Il s´agit d´une série de cas rétrospective uni-centrique. Analyse documentaire des données épidémiologiques, cliniques, radiologiques, anatomopathologiques, thérapeutiques et évolutives de 40 patients. Le glioblastome représentait 47,6% des tumeurs intracrâniennes traitées. L´âge moyen des patients est 52,4±12,3 ans. L´impotence fonctionnelle et les signes d´hypertension intracrânienne dominaient les symptômes. Les tumeurs étaient préférentiellement pariétales (44%) et de grande taille (57,5%). L´aphasie était liée à la taille tumorale (p=0,042) [ABSTRACT FROM AUTHOR]