Virulence factors for hemolytic uremic syndrome, Denmark.

Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print Cited Medium: Print ISSN: 1080-6040 (Print) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE

Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995-

Virulence Factors*/genetics; Escherichia coli/*pathogenicity ; Hemolytic-Uremic Syndrome/*physiopathology; Adhesins, Bacterial/genetics ; Age Factors ; Carrier Proteins/genetics ; Child ; Child, Preschool ; Denmark ; Diarrhea/physiopathology ; Diarrhea/virology ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Escherichia coli Infections/physiopathology ; Escherichia coli Infections/virology ; Escherichia coli Proteins/genetics ; Hemolytic-Uremic Syndrome/virology ; Humans ; Infant ; Risk Factors ; Shiga Toxin 2/genetics

We present an analysis of strain and patient factors associated with the development of bloody diarrhea and hemolytic uremic syndrome (HUS) among Shiga toxin-producing Escherichia coli (STEC) patients registered in Denmark in a 6-year period. Of 343 STEC patients, bloody diarrhea developed in 36.4% and HUS in 6.1%. In a multivariate logistic regression model, risk factors for bloody diarrhea were the eae and stx2 genes, O groups O157 and O103, and increasing age. Risk factors for HUS were presence of the stx2 (odds ratio [OR] 18.9) and eae (OR undefined) genes, being a child, and having bloody diarrhea. O group O157, although associated with HUS in a univariate analysis (OR 4.0), was not associated in the multivariate analysis (OR 1.1). This finding indicates that, rather than the O group, the combined presence of the eae and stx2 genes is an important predictor of HUS.

Comment in: Emerg Infect Dis. 2005 Mar;11(3):503-4; author reply 504-5. doi: 10.3201/eid1103.040462. (PMID: 15789492)

Eur J Clin Microbiol Infect Dis. 2003 Dec;22(12):726-30. (PMID: 14614596)
J Infect Dis. 2002 Jan 1;185(1):74-84. (PMID: 11756984)
JAMA. 2002 Aug 28;288(8):996-1001. (PMID: 12190370)
J Clin Microbiol. 2002 Dec;40(12):4585-93. (PMID: 12454157)
J Med Microbiol. 2003 Nov;52(Pt 11):941-7. (PMID: 14532337)
J Clin Microbiol. 1999 Jul;37(7):2312-6. (PMID: 10364603)
Infect Immun. 1977 Dec;18(3):775-9. (PMID: 338490)
J Infect Dis. 1989 Dec;160(6):994-8. (PMID: 2685131)
Clin Microbiol Rev. 1998 Jan;11(1):142-201. (PMID: 9457432)
Emerg Infect Dis. 1998 Oct-Dec;4(4):635-9. (PMID: 9866741)
J Clin Microbiol. 1999 Mar;37(3):497-503. (PMID: 9986802)

0 (Adhesins, Bacterial)
0 (Carrier Proteins)
0 (Escherichia coli Proteins)
0 (Shiga Toxin 2)
0 (Virulence Factors)
147094-99-3 (eaeA protein, E coli)

Date Created: 20040618 Date Completed: 20040820 Latest Revision: 20220410

20250114

PMC3323205

10.3201/eid1005.030576

15200817