Inositol 1,4,5-trisphosphate receptors as signal integrators.

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المؤلفون: Patterson RL;Patterson RL; Boehning D; Snyder SH
المصدر:
Annual review of biochemistry [Annu Rev Biochem] 2004; Vol. 73, pp. 437-65.
نوع النشر :
Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
اللغة:
English

معلومة اضافية
- المصدر:
  Publisher: Annual Reviews Country of Publication: United States NLM ID: 2985150R Publication Model: Print Cited Medium: Print ISSN: 0066-4154 (Print) Linking ISSN: 00664154 NLM ISO Abbreviation: Annu Rev Biochem Subsets: MEDLINE
- بيانات النشر:
  Original Publication: Palo Alto, CA : Annual Reviews
- الموضوع:
  Calcium Channels/*metabolism ; Receptors, Cytoplasmic and Nuclear/*metabolism; Adenosine Triphosphate/metabolism ; Animals ; Apoptosis/physiology ; Calcium Channels/chemistry ; Calcium Signaling ; Calcium-Binding Proteins/chemistry ; Calcium-Binding Proteins/metabolism ; Humans ; Inositol 1,4,5-Trisphosphate Receptors ; Macromolecular Substances ; Models, Biological ; Models, Molecular ; Phosphorylation ; Protein Conformation ; Receptors, Cytoplasmic and Nuclear/chemistry ; Signal Transduction ; Tacrolimus Binding Protein 1A/chemistry ; Tacrolimus Binding Protein 1A/metabolism
- نبذة مختصرة :
  The inositol 1,4,5 trisphosphate (IP3) receptor (IP3R) is a Ca2+ release channel that responds to the second messenger IP3. Exquisite modulation of intracellular Ca2+ release via IP3Rs is achieved by the ability of IP3R to integrate signals from numerous small molecules and proteins including nucleotides, kinases, and phosphatases, as well as nonenzyme proteins. Because the ion conduction pore composes only approximately 5% of the IP3R, the great bulk of this large protein contains recognition sites for these substances. Through these regulatory mechanisms, IP3R modulates diverse cellular functions, which include, but are not limited to, contraction/excitation, secretion, gene expression, and cellular growth. We review the unique properties of the IP3R that facilitate cell-type and stimulus-dependent control of function, with special emphasis on protein-binding partners.
- Number of References:
  185
- Grant Information:
  DA-000266 United States DA NIDA NIH HHS; DA-00074 United States DA NIDA NIH HHS; MH-18501 United States MH NIMH NIH HHS; NH65090 United States NH NIH HHS; NS043850 United States NS NINDS NIH HHS
- الرقم المعرف:
  0 (Calcium Channels)
  0 (Calcium-Binding Proteins)
  0 (ITPR1 protein, human)
  0 (Inositol 1,4,5-Trisphosphate Receptors)
  0 (Macromolecular Substances)
  0 (Receptors, Cytoplasmic and Nuclear)
  8L70Q75FXE (Adenosine Triphosphate)
  EC 5.2.1.- (Tacrolimus Binding Protein 1A)
- الموضوع:
  Date Created: 20040611 Date Completed: 20041008 Latest Revision: 20131121
- الموضوع:
  20231215
- الرقم المعرف:
  10.1146/annurev.biochem.73.071403.161303
- الرقم المعرف:
  15189149

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Inositol 1,4,5-trisphosphate receptors as signal integrators.

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