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Diet quality indices and dietary patterns are associated with plasma metabolites in colorectal cancer patients.
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- المؤلفون: Geijsen, Anne J. M. R.; Kok, Dieuwertje E.; van Zutphen, Moniek; Keski-Rahkonen, Pekka; Achaintre, David; Gicquiau, Audrey; Gsur, Andrea; Kruyt, Flip M.; Ulrich, Cornelia M.; Weijenberg, Matty P.; de Wilt, Johannes H. W.; Wesselink, Evertine; Scalbert, Augustin; Kampman, Ellen; van Duijnhoven, Fränzel J. B.
- المصدر:
European Journal of Nutrition; Sep2021, Vol. 60 Issue 6, p3171-3184, 14p, 1 Diagram, 4 Charts, 1 Graph
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
Purpose: Emerging evidence suggests that diet is linked to survival in colorectal cancer patients, although underlying mechanisms are not fully understood. The aim of this study was to evaluate whether dietary exposures are associated with metabolite concentrations in colorectal cancer patients. Methods: Concentrations of 134 metabolites of the Biocrates AbsoluteIDQ p180 kit were quantified in plasma samples collected at diagnosis from 195 stage I-IV colorectal cancer patients. Food frequency questionnaires were used to calculate adherence to the World Cancer Research Fund (WCRF) dietary recommendations and the Dutch Healthy Diet (DHD15) index as well as to construct dietary patterns using Principal Component Analysis. Multivariable linear regression models were used to determine associations between dietary exposures and metabolite concentrations. All models were adjusted for age, sex, body mass index, smoking status, analytical batch, cancer stage, and multiple testing using false discovery rate. Results: Participants had a mean (SD) age of 66 (9) years, were mostly men (60%), and mostly diagnosed with stage II and III cancer. For the dietary pattern analyses, Western, Carnivore, and Prudent patterns were identified. Better adherence to the WCRF dietary recommendations was associated with lower concentrations of ten phosphatidylcholines. Higher intake of the Carnivore pattern was associated with higher concentrations of two phosphatidylcholines. The DHD15-index, Western pattern, or Prudent pattern were not associated with metabolite concentrations. Conclusion: In the current study, the WCRF dietary score and the Carnivore pattern are associated with phosphatidylcholines. Future research should elucidate the potential relevance of phosphatidylcholine metabolism in the colorectal cancer continuum. Clinical trial registry: ClinicalTrials.gov Identifier: NCT03191110. [ABSTRACT FROM AUTHOR]
- نبذة مختصرة :
Copyright of European Journal of Nutrition is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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